High Blood Pressure Drugs
The medical approach to addressing high blood pressure is to artificially lower your blood pressure through biochemical changes instead of fixing the root cause of your high blood pressure. Refer to Chapter 15 of Death to Diabetes for a list of the root causes, and how to address them -- without the drugs.
Everyone with high blood pressure doesn't need to be treated with drugs. Most people may do just as well by reducing weight, eating properly and getting the right amount of physical activity.
Also, don't insist that your doctor use a certain drug because you've read or heard about its effect on other people. You can have a serious side effect if you take a "wonder drug" that isn't right for you. You should ask your doctor and insist on non-drug solutions for your blood pressure. Unfortunately, most doctors are not trained to provide non-drug solutions for your health -- they are trained to "push" the pharmaceutical company's drugs.
Although high blood pressure and diabetes are "connected" and are driven by similar root causes, instead of addressing these root causes, Western Medicine focuses on the symptoms. As a result, more than 82% of Type 2 diabetics are doomed to take multiple drugs to suppress the symptoms instead of address what's actually causing the health problems.
Danger! Your blood pressure is artificially lowered while you are taking these HBP drugs; and, your heart muscle and cardiovascular system become biochemically dependent on these drugs. 
As a result, it becomes difficult to get off these drugs once you start -- so insist on a non-drug solution, if possible.
Are you aware that most high blood pressure drugs cause damage to the kidneys? Yes, the kidneys -- the organs that control your blood pressure!
And, are you aware that some high blood pressure drugs actually
weaken your heart muscle? And, you can never ever come off those drugs!!
Types of Blood Pressure Drugs
There are several major types of high blood pressure (HBP) drugs:
-- Diuretics
-- Angiotensin-converting enzyme (ACE) inhibitors
-- Angiotensin II receptor blockers
-- Calcium antagonists (calcium channel blockers)
-- Beta-blockers
-- Sympathetic nerve inhibitors
-- Vasodilators
These drugs help to lower your blood pressure and may be helpful in acute health-threatening situations, but these drugs are dangerous because they slowly cause damage to the liver, kidneys, and heart muscle, and, can eventually lead to congestive heart failure!
Diuretics: rid the body of excess fluids and salt (sodium) and should be used as initial therapy for most patients.
Examples:
hydrochlorothiazide (Esidrix, Hydrodiuril, Microzide)
chlorthalidone (Hygroton)
furosemide (Lasix)
indapamide (Lozol)
metolazone (Mykrox, Zaroxolyn)
amiloride hydrochloride (Midamar)
spironolactone (Aldactone)
triamterene (Dyrenium)
ACE inhibitors: interfere with the body's production of angiotensin, a chemical that causes the arteries to constrict.
Examples:
benazepril hydrochloride (Lotensin)
captopril (Capoten)
enalapril maleate (Vasotec)
fosinopril sodium (Monopril)
lisinopril (Prinivil, Zestril)
moexipril (Univasc)
quinapril hydrochloride (Accupril)
ramipril (Altace)
trandolapril (Mavik)
Angiotensin II receptor blockers: block the effects of angiotensin.
Examples:
candesartan (Atacand)
irbesarten (Avapro)
losartin potassium (Cozaar)
telmisartan (Micardis)
valsartan (Diovan)
Beta-blockers: reduce the heart rate and the heart's output of blood.
Examples:
acebutolol (Sectral)
atenolol (Tenormin)
betaxolol (Kerlone)
bisoprolol fumarate (Zebeta)
carteolol hydrochloride (Cartrol)
metoprolol tartrate (Lopressor)
metoprolol succinate (Toprol-XL)
nadolol (Corgard)
penbutolol sulfate (Levatol)
pindolol* (Visken)
propranolol hydrochloride (Inderal)
timolol maleate (Blocadren)
Sympathetic nerve inhibitors: reduce blood pressure by inhibiting the sympathetic nerves from constricting blood vessels. Sympathetic nerves go from the brain to all parts of the body, including the arteries. They can cause the arteries to constrict, raising blood pressure.
Examples:
hydrochlorothiazide
Vasodilators: relax the smooth muscle in the walls of the blood vessels (especially the arterioles), allowing the vessel to dilate (widen).
Examples:
clonidine (Catapres)
doxazosin (Cardura)
guanfacine (Tenex)
hydralazine (Apresoline)
methyldopa (Aldomet)
minoxidil (Loniten)
prazosin (Minipress)
terazosin (Hytrin)
Calcium antagonists (calcium channel blockers): reduce the heart rate and relax blood vessels.
Examples:
amlodipine besylate (Norvasc)
diltiazem hydrochloride (Cardizem CD, Cardizem SR, Dilacor XR, Tiazac)
felodipine (Plendil)
isradipine (DynaCirc, DynaCirc CR)
nicardipine (Cardene SR)
nifedipine (Adalat CC, Procardia XL)
nisoldipine (Sular)
verapamil hydrochloride (Calan SR, Covera HS, Isoptin SR, Verelan)
*********************************************************
High Cholesterol Drugs
Cholesterol-lowering drugs, especially the statin drugs, have become very popular. In fact, one of the statin drugs (Lipitor) has become the Number 1-selling prescription in America. Why is that? Because the pharmaceutical companies and the doctors convinced us that these drugs would prevent heart attacks and strokes. But, the latest studies show that these drugs do not prevent heart attacks or strokes, and, may, in fact, trigger a heart attack or stroke!
Several recent studies have concluded that statin drugs cause diabetes! -- by decreasing cellular insulin sensitivity, leading to pre-diabetes, and full-blown diabetes!
Refer to Chapter 15 of Death to Diabetes for a list of the root causes of high cholesterol, and how to address them -- without the drugs.
Types of Cholesterol-lowering Drugs:
-- Statins
-- Niacin
-- Bile-acid resins
-- Fibric acid derivatives (fibrates)
-- Cholesterol absorption inhibitors
Statins: block the production of cholesterol in the liver, but also blocks the production of a key nutrinet called CoQ10.
Side effects: intestinal problems, liver damage, and in a few people, muscle tenderness.
Brand names: Crestor, Lipitor, Lescol, Mevacor, Pravachol, Zocor
Niacin (Nicotinic acid): is a B-complex vitamin that lowers LDL cholesterol and may raise HDL cholesterol.
Side Effects: flushing, itching, tingling and headache.
Brand names: Nicolar, Niaspan
Bile-acid resins: work inside the intestine, where they bind to bile from the liver and prevent it from being reabsorbed into the circulatory system. Bile is made largely from cholesterol, so these drugs work by depleting the body's supply of cholesterol.
Side effects: constipation, gas and upset stomach.
Brand names: Questran, Questran Light, Colestid, WelCho
Fibrates: reduce the production of triglycerides and can increase HDL cholesterol.
Side effects: upset stomach, diarrhea, temporary dizziness, temporary blurred vision, anemia, gallstones, muscle pains.
Brand names: Atromid, Tricor, Lopid
Note: You should avoid taking other cholesterol-lowering drugs and anticoagulants. Also, you should not drink grapefruit juice and limit fresh grapefruit consumption while taking cholesterol-lowering drugs, as it can interfere with the liver's ability to metabolize these medications.
WARNING About Statin Drugs
Statin drugs can impair the production of certain proteins involved in muscle metabolism and function. This can result in muscle pain and tenderness — a condition known as statin myopathy. If you notice moderate muscle aching, stop taking your statin medication and contact your doctor. Muscle aching usually goes away within a couple of weeks after stopping the statin drug.
In severe cases, statins may cause muscle cells to break down. This rare but potentially life-threatening side effect is known as rhabdomyolysis. The most common signs and symptoms of rhabdomyolysis include:
-- Severe muscle aching throughout the entire body
-- Muscle weakness
-- Dark or cola-colored urine
The higher the dose of statins, the higher the risk of rhabdomyolysis. The risk also increases if certain drugs — including cyclosporine and gemfibrozil (Lopid) — are taken in combination with statins.
If you have signs and symptoms of rhabdomyolysis, stop taking your statin medication immediately and seek medical treatment right away. If necessary, your doctor may take steps to help prevent kidney damage and other complications.
Prescription Drugs -- The Answer?
Prescription drugs help to (artificially) lower your blood pressure,
blood glucose, and cholesterol -- but, are they really the answer to you
improving your health? Go to the following web pages for more
information about the danger of
prescription drugs:
Note: If you want to safely wean off these dangerous drugs, start a sound nutritional program and get the
How to Wean Off Drugs Safely ebook.
References
- ^ Alsheikh-Ali
AA; Maddukuri, PV; Han, H; Karas, RH (2007). "Effect of the Magnitude
of Lipid Lowering on Risk of Elevated Liver Enzymes, Rhabdomyolysis, and
Cancer: Insights From Large Randomized Statin Trials". Journal of the American College of Cardiology 50 (5): 409–418. doi:10.1016/j.jacc.2007.02.073. PMID 17662392.
- ^ a b Poynter JN, Gruber SB, Higgins PD, et al. (2005). "Statins and the risk of colorectal cancer". N. Engl. J. Med. 352 (21): 2184–92. doi:10.1056/NEJMoa043792. PMID 15917383. http://content.nejm.org/cgi/content/full/352/21/2184.
- ^ Mayo clinic: article on interference between grapefruit and medication
- ^ Kane GC, Lipsky JJ (2000). "Drug-grapefruit juice interactions". Mayo Clin. Proc. 75 (9): 933–42. doi:10.4065/75.9.933. PMID 10994829.
- ^ Miettinen TA (March 1982). "Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins". Journal of Lipid Research 23 (3): 466–73. PMID 7200504. http://www.jlr.org/cgi/content/abstract/23/3/466.
- ^ Saito
Y; Yoshida S; Nakaya N; Hata Y; Goto Y (Jul-Aug 1991). "Comparison
between morning and evening doses of simvastatin in hyperlipidemic
subjects. A double-blind comparative study". Arterioscler Thromb 11 (4): 816–26. PMID 2065035.
- ^ Wallace
A; Chinn D; Rubin G (4 October 2003). "Taking simvastatin in the
morning compared with in the evening: randomised controlled trial". British Medical Journal 327 (7418): 788. doi:10.1136/bmj.327.7418.788. PMID 14525878.
- ^ Cilla
DD Jr; Gibson DM; Whitfield LR; Sedman AJ (July 1996). "Pharmacodynamic
effects and pharmacokinetics of atorvastatin after administration to
normocholesterolemic subjects in the morning and evening". Journal of Clinical Pharmacology 36 (7): 604–9. PMID 8844442.
- ^ Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL, Brown MS (1986). "Mevinolin,
an inhibitor of cholesterol synthesis, induces mRNA for low density
lipoprotein receptor in livers of hamsters and rabbits" (PDF). Proc. Natl. Acad. Sci. U.S.A. 83 (21): 8370–4. doi:10.1073/pnas.83.21.8370. PMC 386930. PMID 3464957. http://www.pnas.org/cgi/reprint/83/21/8370. PMC: 386930 Full text at
- ^ Furberg CD (19 January 1999). "Natural Statins and Stroke Risk". Circulation 99PMID 9892578. http://circ.ahajournals.org/cgi/content/full/99/2/185. (2): 185–188.
- ^ Ridker PM, Danielson E, Fonseca FAH, et al. (2008). "Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein". NEJM 359 (21): 2195–207. doi:10.1056/NEJMoa0807646. PMID 18997196. http://content.nejm.org/cgi/reprint/NEJMoa0807646v1.pdf.
- ^ The interactive pathway map can be edited at WikiPathways: "StatinPathway_WP430". http://www.wikipathways.org/index.php/Pathway:WP430.
- ^ Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP, Ridker PM (2004). "Pharmacogenetic study of statin therapy and cholesterol reduction". JAMA 291 (23): 2821–7. doi:10.1001/jama.291.23.2821. PMID 15199031. http://jama.ama-assn.org/cgi/content/full/291/23/2821.
- ^ Iakoubova,
O. A.; Sabatine, M. S.; Rowland, C. M.; Tong, C. H.; Catanese, J. J.;
Ranade, K.; Simonsen, K. L.; Kirchgessner, T. G. et al. (2008).
"Polymorphism in KIF6 Gene and Benefit from Statins After Acute Coronary
Syndromes: Results from the PROVE IT-TIMI 22 Study". Journal of the American College of Cardiology 51 (4): 449–55. doi:10.1016/j.jacc.2007.10.017. PMID 18222355. edit
- ^ The SEARCH Collaborative Group (2008). "SLCO1B1 Variants and Statin-Induced Myopathy - A Genomewide Study". NEJM 359: 789–799. doi:10.1056/NEJMoa0801936. PMID 18650507. http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801936.
- ^ Endo A (1 November 1992). "The discovery and development of HMG-CoA reductase inhibitors" (PDF). J. Lipid Res. 33 (11): 1569–82. PMID 1464741. http://www.jlr.org/cgi/reprint/33/11/1569.
- ^ Steinberg, Daniel. The Cholesterol Wars: The Skeptics vs. The Preponderance of Evidence. Academic Press, 2007, pp. 6–9.
- ^ "Randomised
trial of cholesterol lowering in 4444 patients with coronary heart
disease: the Scandinavian Simvastatin Survival Study (4S)". Lancet 344 (8934): 1383–9. November 1994. PMID 7968073.
- ^ Abramson J, Wright J (2007). "Are lipid-lowering guidelines evidence-based?". Lancet 369 (9557): 168–9. doi:10.1016/S0140-6736(07)60084-1. PMID 17240267.
- ^ Ravnskov U, Rosch P, Sutter M, Houston M (2006). "Should we lower cholesterol as much as possible?". BMJ 332 (7553): 1330–2. doi:10.1136/bmj.332.7553.1330. PMC 1473073. PMID 16740566. http://www.bmj.com/cgi/content/full/332/7553/1330.