Clinical Studies for Reversing Type 2 Diabetes

Scientists conduct various clinical trials as a part of their clinical research in order to look at new ways to prevent, detect, or treat disease. By doing this, it helps to support medical advances.

Researchers also use clinical trials to look at other aspects of care, such as improving the quality of life for people with chronic illnesses.

The following is a list of some the many clinical studies and references that provide medical evidence that Type 2 diabetes can be controlled, managed and reversed into remission by making nutritional and lifestyle changes -- instead of relying solely on diabetic medications.

Hopefully, by sharing this information, this will give you hope that you can gain control over your diabetes naturally instead of the drugs and your diabetes controlling you.

Definition of "Reverse Type 2 Diabetes"

There are two primary definitions of "reverse Type 2 diabetes" that you'll come across on the Internet. 

The primary definition that most websites use is the one that claims that "reverse Type 2 diabetes" is a cure for Type 2 diabetes. However, if you return to eating white rice, potatoes, pasta, bread and other high glycemic foods, your blood sugar will rise and your diabetes will return. So, their claim is false and misleading.

The second definition of "reverse Type 2 diabetes" is to put the disease into remission -- similar to what happens with some cancer patients who are able to put their disease into remission. But, again, if you return to eating the high glycemic foods, your blood sugar will rise and the diabetes will return and come out of remission. However, in this case, the claim is not false and misleading. 

Our definition of "reversed Type 2 diabetes" is based on the second definition. 

With our diabetes program, we define "reversed Type 2 diabetes" as being able to put the disease "into remission" and stop its progress, based on the following medical criteria:

Fasting blood glucose (FBG): Your fasting blood glucose must be consistently less than 100 mg/dl and maintained at that level for at least 3 consecutive months.  [This is part of the criteria to reach Stage 4 of our Death to Diabetes Program]

Postprandial blood glucose (PBG): Your postprandial blood glucose must be consistently less than 110 mg/dl 2 hours after a meal and maintained at that level for at least 3 consecutive months.  [This is part of the criteria to reach Stage 4 of our Death to Diabetes Program]

Hemoglobin A1c (HbA1c): Your hemoglobin A1c must be consistently less than 6% and maintained at that level for at least 3 consecutive months. [This is part of the criteria to reach Stage 4 of our Death to Diabetes Program]

Full Remission: If you are able to maintain these numbers for at least 1 year with normal blood pressure and cholesterol numbers, then, your diabetes is into full remission.  [This is part of the criteria to reach Stage 5 of our Death to Diabetes Program]

Prolonged Remission: If you are able to maintain these numbers for at least 5 years along with normal blood pressure and cholesterol numbers and be able to eat high glycemic foods, then, the case could be made that you have completely reversed  and cured your diabetes.  [This is part of the criteria to reach Stage 6 of our Death to Diabetes Program]

Please Note: We are the only diabetes program that we are aware of that clearly defines in measurable terms what is meant by reversing your diabetes.

Author's Perspective: When I was originally diagnosed with Type 2 diabetes in the hospital, all I heard every day was that I would have to be on insulin for the rest of my life. 

Needless to say, during my research, I was surprised to discover so many clinical references on PubMed and other medical databases about the feasibility of managing, controlling and possibly reversing Type 2 diabetes naturally. 

The following is a list of some the many clinical references, abstracts and resources from PubMed and other medical websites that I found; and, used to help write my Death to Diabetes book.

I used some of these clinical references to substantiate many of my nutritional recommendations that support managing and possibly reversing Type 2 diabetes and preventing the onset of diabetic complications. 

Although my focus is primarily on Type 2 diabetes, I included clinical references and abstracts about Type 1 diabetes because there is a lot that parents of Type 1 children need to know about nutrition and how it can affect their children -- positively and negatively.

Note: Today, there are more doctors and additional clinical studies and reports in PubMed and other medical databases that support the claim that Type 2 Diabetes can be controlled,managed and possibly reversed into remission.

FYI: On our General Clinical Studies web page, there are hundreds of clinical references and studies about nutrition, supplements and other topics relating to controlling, managing and reversing Type 2 diabetes.

References: Definition of Reverse Type 2 Diabetes Into  Remission

Incidence of Remission in Adults With Type 2 Diabetes: The Diabetes & Aging Study

Andrew J. Karter, Shantanu Nundy, Melissa M. Parker, Howard H. Moffet and Elbert S. Huang

Diabetes Care 2014 Dec; 37(12): 3188-3195.

“Prolonged remission” was defined as having two or more consecutive normoglycemic HbA1c measurements, all of which were <5.7% [<39 mmol/mol] over a period of at least 60 months. Each definition of remission requires the absence of pharmacologic treatment during the defined observation period.

Recently, the American Diabetes Association (ADA) convened an expert panel to define the term “cure of diabetes”. The ADA consensus statement borrowed from the cancer literature in defining the term “remission” as achieving glycemia below the diabetic range in the absence of active pharmacologic or surgical therapy. It defines the following three mutually exclusive states of remission:

Partial remission, which is subdiabetic hyperglycemia of at least 1 year (A1C level not diagnostic of diabetes [5.7–6.4%; 39–46 mmol/mol], fasting glucose level 100–125 mg/dL [5.6–6.9 mmol/L]);

Complete remission, which is normoglycemia of at least 1 year (A1C level in the normal range [<5.7%; <39 mmol/mol], fasting glucose <100 mg/dL [5.6 mmol/L]); and

Prolonged remission (or “cure”), complete remission of at least 5 years.

In this large cohort of insured adults with type 2 diabetes not treated with bariatric surgery, we found that 1.5% of individuals with recent evidence of clinical diabetes achieved at least partial remission over a 7-year period.

If these results were generalized to the 25.6 million U.S. adults living with type 2 diabetes in 2010 (25), they would suggest that 384,000 adults could experience remission over the next 7 years. However, the rate of prolonged remission was extremely rare (0.007%), translating into only 1,800 adults in the U.S. experiencing remission lasting at least 5 years.

To provide context, 1.7% of the cohort died, while only 0.8% experienced any level of remission, during the calendar year 2006. Thus, the chances of dying were higher than the chances of any remission.

Conclusions: In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.

ADA-UK Definition of Type 2 Diabetes Remission

Diabetes remission in people with Type 2 diabetes means that your blood sugar levels are healthy without needing to take any diabetes medication.

Our research tells us that diabetes remission is most likely nearer to your diagnosis and strongly linked to weight loss.

Our researchers used an HbA1c level of 48mmol/mol (6.5%) or less to define remission.

Some people call this reversing Type 2 diabetes or even a cure, but we prefer the term remission because your diabetes can come back. And there’s no guarantee you will reach remission – the research so far suggests that it isn’t possible for everyone.

Scientists have been busy investigating a new weight management treatment, which includes a low-calorie diet, to help people put their Type 2 diabetes into remission.

We also know that some people in remission got there by losing weight through the Mediterranean diet or a low-carb diet. Everyone’s different and what works for some may not for others.

This ground-breaking study is called DiRECT, short for Diabetes Remission Clinical Trial. The results have already inspired the NHS England to pilot a Type 2 diabetes remission programme later in 2019 and Scotlandare busy rolling out programmes right now.

ADA: How Do We Define Cure of Diabetes? [Remission]

John B. Buse, MD, PHD, Sonia Caprio, MD, William T. Cefalu, MD, Antonio Ceriello, MD, Stefano Del Prato, MD5, Silvio E. Inzucchi, MD, Sue McLaughlin, BS, RD, CDE, CPT, Gordon L. Phillips II, MD, R. Paul Robertson, MD, Francesco Rubino, MD, Richard Kahn, PHD and M. Sue Kirkman, MD

Diabetes Care 2009 Nov; 32(11): 2133-2135.

For a chronic illness such as diabetes, it may be more accurate to use the term remission than cure ... 

Additionally, if cure means remission that lasts for a lifetime, then by definition a patient could never be considered cured while still alive.

Hence, it may make sense operationally to consider prolonged remission of diabetes essentially equivalent to cure. This is analogous to certain cancers, where cure is defined as complete remission of sufficient duration that the future risk of recurrence is felt to be very low.

A remission can be characterized as partial or complete.

Partial remission is sub-diabetic hyperglycemia (A1C not diagnostic of diabetes [<6.5%], fasting glucose 100–125 mg/dl [5.6–6.9 mmol/l]) of at least 1 year's duration in the absence of active pharmacologic therapy or ongoing procedures.

Complete remission is a return to “normal” measures of glucose metabolism (A1C in the normal range, fasting glucose <100 mg/dl [5.6 mmol/l]) of at least 1 year's duration in the absence of active pharmacologic therapy or ongoing procedures.

Remission of type 2 diabetes could be attained, for example, after bariatric/metabolic surgery or with lifestyle efforts such as weight loss and exercise.

Prolonged remission is complete remission that lasts for more than 5 years and might operationally be considered a cure.

In a partial or complete remission of less than 5 years' duration, the goals for treatment of comorbidities (hypertension, dyslipidemia) should remain the same as for those with diabetes (e.g., blood pressure goal <130/80 mmHg).

These definitions and consensus recommendations are based on what the consensus group felt to be reasonable given the therapies of today.

Beating type 2 diabetes into remission | The BMJ

Louise McCombie, researcher,  Wilma Leslie, researcher, Roy Taylor, professor,  Brian Kennon,  Naveed Sattar, professor,  Mike E J Lean, professor

BMJ 2017;358:j4030

Partial remission (no longer having diabetes): Both HbA1c < 6.5% (<48 mmol/mol) and fasting blood glucose 5.6-6.9 mmol/L without antidiabetes drugs (time not specified)

Maintained for 1 year

Complete remission (no longer having prediabetes): Both HbA1c< 6% (<42 mmol/mol) and fasting blood glucose <5.6 mmol/L without antidiabetes drugs (time not specified)

Maintained for 1 year

Previous diagnosis of type 2 diabetes by WHO criteria. HbA1c <6.5% (<48 mmol/mol) or fasting blood glucose<7 mmol/L and 2 hour glucose<11 mmol/L after at least 2 months without antidiabetes medication

Clinical Studies & References: Reversing Type 2 Diabetes 

High rates of diabetes reversal in newly diagnosed Asian Indian young adults with type 2 diabetes mellitus with intensive lifestyle therapy

Results: Reversal/remission rates at 3 months, 1 year, and 2 years were 24 (75%), 24 (75%), and 22 (68.75%), respectively. Seventeen (53.1%) patients achieved complete reversal and seven (21.9%) patients achieved partial reversal at 3 months. Rates of complete and partial remission at 1 year were 50% and 25% and at 2 years were 46.9% and 21.9%, respectively.

Conclusion: Young adults with newly diagnosed type 2 DM have high rates of diabetes reversal and should receive ILT to achieve reversal of diabetes.

J Nat Sci Biol Med. 2017 Jan-Jun; 8(1): 60–63

Vijaya Sarathi, Anish Kolly, H. B. Chaithanya, and C. S. Dwarakanath

Remission of recently diagnosed type 2 diabetes mellitus with weight loss and exercise.

Ades PA1, Savage PD, Marney AM, Harvey J, Evans KA.

Author information: Divisions of Cardiology (Dr Ades and Mr Savage), Endocrinology (Dr Marney), and Nutrition and Food Sciences (Dr Harvey and Ms Evans), University of Vermont Medical Center, Burlington, Vermont.

J Cardiopulm Rehabil Prev. 2015 May-Jun;35(3):193-7. doi: 10.1097/HCR.0000000000000106.

Results: Subjects had a baseline HbA1c of 6.5% to 8.0% (mean 6.8 ± 0.2). Subjects lost 9.7 ± 0.2 kg body weight (9%) and improved peak aerobic capacity by 18%. Two subjects withdrew for medical reasons unrelated to the lifestyle program. Eight of 10 completers (80%) went into partial T2DM remission, with the mean HbA1c decreasing from 6.8 ± 0.2% to 6.2 ± 0.3%.

Conclusions: For individuals with recently diagnosed T2DM willing to undertake a formal lifestyle program, 80% of study completers and 67% of our total population achieved at least a partial T2DM remission at 6 months. Further study of this intervention at the time of diagnosis of T2DM with randomized controls and longer-term followup is warranted.

Behaviour change, weight loss and remission of Type 2 diabetes: a community‐based prospective cohort study
H. Dambha‐Miller A. J. Day J. Strelitz G. Irving S. J. Griffin
Research: Epidemiology
First published: 03 September 2019

Results: Diabetes remission was achieved in 257 participants (30%) at 5‐year follow‐up. Compared with people who maintained the same weight, those who achieved ≥ 10% weight loss in the first year after diagnosis had a significantly higher likelihood of remission. In the subsequent 1–5 years, achieving ≥10% weight loss was also associated with remission.

Conclusion: In a population‐based sample of adults with screen‐detected Type 2 diabetes, weight loss of ≥10% early in the disease trajectory was associated with a doubling of the likelihood of remission at 5 years. This was achieved without intensive lifestyle interventions or extreme calorie restrictions. Greater attention should be paid to enabling people to achieve weight loss following diagnosis of Type 2 diabetes.

Type 2 diabetes remission 1 year after an intensive lifestyle intervention: A secondary analysis of a randomized clinical trial.

Ried-Larsen M, Johansen MY, MacDonald CS, Hansen KB, Christensen R, Wedell-Neergaard AS, Pilmark NS, Langberg H, Vaag AA, Pedersen BK, Karstoft K

Diabetes Obes Metab. 2019 Oct;21(10):2257-2266.

Results: Of the 98 randomized participants, 23% of participants met the criteria for any T2D remission.

Conclusions: The statistically non-significant threefold increased remission rate of T2D in the lifestyle intervention group calls for further large-scale studies to understand how to implement sustainable lifestyle interventions among people with T2D.

Reversing Type 2 Diabetes: A Narrative Review of the Evidence.

Results: Evidence exists that T2D reversal is achievable using bariatric surgery, low-calorie diets (LCD), or carbohydrate restriction (LC). Bariatric surgery has been recommended for the treatment of T2D since 2016 by an international diabetes consensus group. Both the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) now recommend a LC eating pattern and support the short-term use of LCD for weight loss. However, only T2D treatment, not reversal, is discussed in their guidelines.

Conclusion: Given the state of evidence for T2D reversal, healthcare providers need to be educated on reversal options so they can actively engage in counseling patients who may desire this approach to their disease.

Nutrients. 2019 Apr 1;11(4). pii: E766. doi: 10.3390/nu11040766.

Type 2 Diabetes Mellitus (T2DM) “Remission” in Non-bariatric Patients 65 Years and Older

Srikanth Tangelloju, Bert B. Little, Robert J. Esterhay, Guy Brock,2 and A. Scott LaJoie

Author Infomation: Department of Health Management and Systems Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY;

Ohio State University Wexner Medical Center, Columbus, OH;

Department of Health Promotion and Behavioral Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY

Results: 4.97% of patients studied met the definition of T2DM “remission” in the study cohort.

Conclusion: T2DM “remission” in Medicare patients 65 years and older is observed in a community setting in a small proportion of non-bariatric patients.

Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes.

Mottalib A, Sakr M, Shehabeldin M, Hamdy O

Author information: Joslin Diabetes Center, One Joslin Place, Boston, MA

Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction.

J Diabetes Res. 2015;2015:468704. doi: 10.1155/2015/468704. Epub 2015 May 31.

Reversibility of diabetes mellitus: Narrative review of the evidence

Gary Yee Ang. Health Services and Outcomes Research, National Healthcare Group, Singapore 138543, Singapore.

World J Diabetes. 2018 Jul 15; 9(7): 127–131.

Type 2 diabetes mellitus is potentially reversible. A better term to use would be remission which is defined to be achieving glucose level below the diabetic range in the absence of active pharmacologic or surgical therapy. It can further be divided into partial or complete and if complete remission lasts for more than 5 years, it would be considered as prolonged remission.

With bariatric surgery, diabetes remission can be an important outcome to look at after bariatric surgery and there are many risk prediction models which can predict diabetes remission.

A Fasting Diet Could Reverse Diabetes And Repair The Pancreas, Says New Research

David Nield

Researchers have been able to reverse symptoms of diabetes and restore pancreas functions in mice by putting them on a version of the fasting-mimicking diet.

In the latest study, mice were put into the artificial fasting mode for four days a week over a period of several months.

Scientists found this was enough to regenerate beta cells in the pancreas, responsible for storing and releasing insulin. Damaged cells were replaced by working ones.

The next step is to set up a clinical trial in humans, and preparations for that are already underway.

Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance

Jaakko Tuomilehto, M.D., Ph.D., Jaana Lindström, M.S., Johan G. Eriksson, M.D., Ph.D., Timo T. Valle, M.D., Helena Hämäläinen, M.D., Ph.D., Pirjo Ilanne-Parikka, M.D., Sirkka Keinänen-Kiukaanniemi, M.D., Ph.D., Mauri Laakso, M.D., Anne Louheranta, M.S., Merja Rastas, M.S., Virpi Salminen, M.S., Sirkka Aunola, Ph.D., et al., for the Finnish Diabetes Prevention Study Group

Results: The cumulative incidence of diabetes after four years was 11 percent (95 percent confidence interval, 6 to 15 percent) in the intervention group and 23 percent (95 percent confidence interval, 17 to 29 percent) in the control group. During the trial, the risk of diabetes was reduced by 58 percent in the intervention group. The reduction in the incidence of diabetes was directly associated with changes in lifestyle.

Conclusions: Type 2 diabetes can be prevented by changes in the lifestyles of high-risk subjects. 

Calorie restriction for long-term remission of type 2 diabetes

Roy Taylor, director of Newcastle Magnetic Resonance Centre

Clin Med (Lond). 2019 Jan; 19(1): 37–42.

Results: In a high proportion of those with short duration diabetes a robust and practical means has been developed to achieve or re-establish non-diabetic glucose control long term.

The data is in: Eat right, reduce your risk of diabetes.

Robert H. Shmerling, MD

Faculty Editor, Harvard Health Publishing

Harvard Health Blog: Researchers publishing in PLoS Medicine describe a study of more than 200,000 people in the U.S. who participated in health surveys over a 20-year period. They found that:

People who chose diets that were predominately of plant-based foods developed type 2 diabetes 20% less often than the rest of the study subjects.

For those with the very healthiest plant-based diets (including fruits, vegetables, nuts, beans, and whole grains), the reduction in type 2 diabetes was 34%.

Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis

Yoko Yokoyama, Neal D. Barnard, Susan M. Levin, Mitsuhiro Watanabe

Results: Consumption of vegetarian diets was associated with a significant reduction in HbA1c (-0.39 percentage point; 95% confidence interval), and a non-significant reduction in fasting blood glucose concentration (-0.36 mmol/L; 95% confidence interval).

Conclusions: Consumption of vegetarian diets is associated with improved glycemic control in type 2 diabetes.

Can Type 2 Diabetes Be Prevented?

Yes! You can prevent or delay type 2 diabetes with proven, achievable lifestyle changes even if you’re at high risk.

Prediabetes: Your Chance to Prevent Type 2 Diabetes

The good news is that if you have prediabetes, the CDC-led National Diabetes Prevention Program can help you make lifestyle changes to prevent or delay type 2 diabetes and other serious health problems.

Additional References:

Clinical references 2

Remission of type 2 diabetes: a position statement from the Association of British Clinical Diabetologists (ABCD) and the Primary Care Diabetes Society (PCDS)

Dinesh Nagi, Clare Hambling, Roy Taylor

This joint Association of British Clinical Diabetologists (ABCD) and the Primary Care Diabetes Society (PCDS) position statement reviews the current evidence related to remission of type 2 diabetes. We believe that there is ample evidence to support the statement that it is possible to achieve remission in type 2 diabetes.

Type 2 diabetes remission possible with 'achievable' weight loss

Source: University of Cambridge

Journal Reference: H. Dambha-Miller, A. J. Day, J. Strelitz, G. Irving, S. J. Griffin. Behaviour change, weight loss and remission of Type 2 diabetes: a community-based prospective cohort study. Diabetic Medicine, 2019.

Summary: People who achieve weight loss of 10% or more in the first five years following diagnosis with type 2 diabetes have the greatest chance of seeing their disease go into remission, according to a new study.

The findings suggest that it is possible to recover from the disease without intensive lifestyle interventions or extreme calorie restrictions.

The researchers found that 257 participants (30%) participants were in remission at five-year follow-up. People who achieved weight loss of 10% or more within the first five years after diagnosis were more than twice as likely to go into remission compared to people who maintained the same weight.

"We've known for some time now that it's possible to send diabetes into remission using fairly drastic measures such as intensive weight loss programmes and extreme calorie restriction," says Dr Hajira Dambha-Miller from the Department of Public Health and Primary Care.

"These interventions can be very challenging to individuals and difficult to achieve. But, our results suggest that it may be possible to get rid of diabetes, for at least five years, with a more modest weight loss of 10%. This will be more motivating and hence more achievable for many people."

Senior author Professor Simon Griffin of the MRC Epidemiology Unit added: "This reinforces the importance of managing one's weight, which can be achieved through changes in diet and increasing physical activity. Type 2 diabetes, while a chronic disease, can lead to significant complications, but as our study shows, can be controlled and even reversed."

Just a Little Weight Loss Can Put Diabetes Into Remission

By Serena Gordon, Health Day Reporter

HealthDay News -- British researchers have good news for people with type 2 diabetes -- you don't need to lose a ton of weight to make a difference in your health.

In fact, they found that losing just 10% of your body weight during the first five years you have the disease can lead to remission of type 2 diabetes. That weight loss would be 18 pounds for someone who weighs 180 pounds.

"Even small amounts of weight loss can help you achieve remission. Extreme dieting and exercising are not necessary," said study author Dr. Hajira Dambha-Miller, a general practice physician and clinical lecturer at the University of Cambridge School of Clinical Medicine, in the United Kingdom.

"Type 2 diabetes should no longer be seen as a lifelong disease," she added. The disease can essentially be cured if you lose weight and keep it off, according to Dr. Dambha-Miller.

Intensive exercise coupled with a modest weight loss of 7% or less of body weight brought on remission in almost 12% of people in one study, according to the new report.

For the new study, the researchers followed the health of almost 900 people newly diagnosed with type 2 diabetes for five years. The study participants, aged 40 to 69, provided information on weight, activity levels, diet and alcohol consumption.

Thirty percent of the group had achieved type 2 diabetes remission at the five-year follow-up. Those who had achieved a 10% weight loss were 77% more likely to be in remission after five years, the findings showed.

Dr. Berhane Seyoum, chief of endocrinology at Detroit Medical Center and Wayne State University in Michigan, wasn't involved in the current research, but said the findings are encouraging. Seyoum also noted that any amount of weight loss can help the body use insulin better and will help with diabetes management.

"People with type 2 diabetes can be encouraged to lose weight, and it doesn't matter how. They can do whatever is convenient for them. Controlling diabetes keeps you healthy, gives you more energy and makes you feel better," he said.

The study was published online recently in the journal Diabetic Medicine.

Type 2 diabetes in newly diagnosed 'can be reversed'

This story is part of NPR's reporting partnership with Nashville Public Radio and Kaiser Health News.

An extreme eight-week diet of 600 calories a day can reverse Type 2 diabetes in people newly diagnosed with the disease, says a Diabetologia study.

Newcastle University researchers found the low-calorie diet reduced fat levels in the pancreas and liver, which helped insulin production return to normal.

Seven out of 11 people studied were free of diabetes three months later, say findings published in the journal.

More research is needed to see whether the reversal is permanent, say experts.

But Keith Frayn, professor of human metabolism at the University of Oxford, said the Newcastle study was important.

"People who lose large amounts of weight following surgery to alter their stomach size or the plumbing of their intestines often lose their diabetes and no longer need treatment.

"This study shows that a period of marked weight loss can produce the same reversal of Type 2 diabetes.

"It offers great hope for many people with diabetes, although it must be said that not everyone will find it possible to stick to the extremely low-calorie diet used in this study."

Dr Iain Frame, director of research at Diabetes UK, which funded the study, said the diet was not an easy fix.

"Such a drastic diet should only be undertaken under medical supervision. Despite being a very small trial, we look forward to future results particularly to see whether the reversal would remain in the long term."

Clinical Case of Type 2 Diabetes Remission.

Mustafayeva S, Mirzazada V.

Author information: Azerbaijan Association of Endocrinology, Diabetology and Therapeutical Education, Baku, Republic of Azerbaijan.

Authors present a clinical case of a 48-year-old male patient diagnosed with type 2 diabetes mellitus (with insulin resistance), obesity class II, alcoholic liver disease and dyslipidemia.

Results: Patient was able to achieve a T2DM remission after lifestyle modification by using low-calorie (1500-1800 kcal), rather than extreme diet, and a significant increase in physical activity.

Conclusion: This result demonstrates that not only biofuel intake decrease, but also increase of biofuel consumption (in optimal situation all together) may be a really effective way of achieving diabetes remission in obese patients.

Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders.

Steven S, Hollingsworth KG, Al-Mrabeh A, Avery L, Aribisala B, Caslake M, Taylor R

Diabetes Care. 2016 May; 39(5):808-15. [PubMed]

Results: Weight fell (98.0 ± 2.6 to 83.8 ± 2.4 kg) and remained stable over 6 months (84.7 ± 2.5 kg). Twelve of 30 participants achieved fasting plasma glucose <7 mmol/L after return to isocaloric diet (responders), and 13 of 30 after 6 months. Responders had a shorter duration of diabetes and a higher initial fasting plasma insulin level. HbA1c fell from 7.1 ± 0.3 to 5.8 ± 0.2% (55 ± 4 to 40 ± 2 mmol/mol) in responders and from 8.4 ± 0.3 to 8.0 ± 0.5% (68 ± 3 to 64 ± 5 mmol/mol) in nonresponders, remaining constant at 6 months (5.9 ± 0.2 and 7.8 ± 0.3% [41 ± 2 and 62 ± 3 mmol/mol], respectively). The responders were characterized by return of first-phase insulin response.

Conclusions: A robust and sustainable weight loss program achieved continuing remission of diabetes for at least 6 months in the 40% who responded to a VLCD by achieving fasting plasma glucose of <7 mmol/L. T2DM is a potentially reversible condition.

Very-Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiologic Changes in Responders and Nonresponders

Sarah Steven, Kieren G. Hollingsworth, Ahmad Al-Mrabeh, Leah Avery,Benjamin Aribisala, Muriel Caslake, Roy Taylor

Diabetes Care 2016 Mar; dc151942.

Conclusions: A robust and sustainable weight loss program achieved continuing remission of diabetes for at least 6 months in the 40% who responded to a VLCD by achieving fasting plasma glucose of <7 mmol/L. T2DM is a potentially reversible condition.

Weight management program can put type 2 diabetes into remission

Date: December 5, 2017
Source: The Lancet
Summary: Type 2 diabetes can be reversed following an intensive weight management program, according a randomized trial in adults who have had the condition for up to 6 years. Almost half of participants achieved and maintained diabetes remission at one year without antidiabetic medications.

Most studies do show Type 2 diabetes, in most patients, marching in pretty much one direction. But Taylor says those studies also involve people who continue to gain weight, which is typical among diabetics.

"Doctors tell their patients, 'You've got a lifelong condition. We know it's going to steadily get worse.' Then they turn around, and their patients aren't losing weight or doing exercise, but they've given them this utterly depressing message," he says.

Taylor's research finds that if a patient loses 30 pounds or so, diabetes can be reversed in its early stages. Taylor prescribes a strict liquid diet and limited exercise — at first — so as not to stimulate the appetite. People with Type 2 diabetes need to lose fat from the liver and pancreas.

Even the American Diabetes Association has been changing its views. The advocacy group has a new position on Type 2 reversal: "If a patient wishes to aim for remission of type 2 diabetes, particularly within 6 years of diagnosis, evidence-based weight management programs are often successful."

John Buse, chief of endocrinology at the University of North Carolina medical school, helped write the American Diabetes Association's revised guidance. "We've known, literally since the 17th century, that diet is the key to managing diabetes," he says.

But it's hard to write a prescription for lifestyle change.

Diabetes is not necessarily a one-way street.
PCRM Clinical Research
February 15, 2005
Diabetes: Can a Vegan Diet Reverse Diabetes?
By Andrew Nicholson, M.D.
Early studies suggest that persons with type 2 diabetes can improve and, in some cases, even reverse the disease by switching to an unrefined, vegan diet. This is based on a carefully controlled test performed by PCRM.

Working with Georgetown University, PCRM compared two different diets: a high-fiber, low-fat, vegan diet and the more commonly used American Diabetes Association (ADA) diet.

Fasting blood sugars decreased 59 percent more in the vegan group than in the ADA group. And, while the vegans needed less medication to control their blood sugars, the ADA group needed just as much medicine as before. The vegans were taking less medicine, but were in better control.

While the ADA group lost an impressive 8 pounds, on average, the vegans lost nearly 16 pounds. Cholesterol levels also dropped more substantially in the vegan group compared to the ADA group.

Remission of Recently Diagnosed Type 2 Diabetes Mellitus with Weight Loss and Exercise

Philip A. Ades, MD, Patrick D. Savage, MS,1 Annis M. Marney, MD, Jean Harvey, PhD, RD, and Kimberly A. Evans, RD

J Cardiopulm Rehabil Prev. 2015 May-Jun; 35(3): 193–197.

Results: Subjects had a baseline HbA1c of 6.5-8.0% (mean 6.8±0.2). Subjects lost 9.7±5.2kgs body weight (9%) and improved peak aerobic capacity by 18%. Two subjects withdrew for medical reasons unrelated to the lifestyle program. Eight of 10 completers (80%) went into partial T2DM remission with the mean HbA1c decreasing from 6.8±0.2 to 6.2±0.3% (P<0.001).

Conclusions: For individuals with recently diagnosed T2DM willing to undertake a formal lifestyle program, 80% of study completers and 67% of our total population achieved at least a partial T2DM remission at 6 months. Further study of this intervention at the time of diagnosis of T2DM with randomized controls and longer-term follow-up is warranted.

Incidence of Remission in Adults With Type 2 Diabetes: The Diabetes & Aging Study

Andrew J. Karter,corresponding author Shantanu Nundy, Melissa M. Parker, Howard H. Moffet, and Elbert S. Huang

Diabetes Care. 2014 Dec; 37(12): 3188–3195.

Results: The incidence density (remissions per 1,000 person-years; 95% CI) of partial, complete, or prolonged remission was 2.8%. The 7-year cumulative incidence of achieving any remission was 1.60%, and 4.6% in the subgroup with new-onset diabetes (<2 years since diagnosis). After adjusting for demographic and clinical characteristics, correlates of remission included age >65 years, African American race, <2 years since diagnosis, baseline HbA1c level <5.7% (<39 mmol/mol), and no diabetes medication at baseline.

Conclusions: In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.

Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R.

Diabetologia. 2011 Oct;54(10):2506-14.

Results: After 1 week of restricted energy intake, fasting plasma glucose normalised in the diabetic group (from 9.2?±?0.4 to 5.9?±?0.4 mmol/l). Insulin suppression of hepatic glucose output improved from 43?±?4% to 74?±?5%. Hepatic triacylglycerol content fell from 12.8?±?2.4% in the diabetic group to 2.9?±?0.2% by week 8. The first-phase insulin response increased during the study period (0.19?±?0.02 to 0.46?±?0.07 nmol min) and approached control values (0.62?±?0.15 nmol min). Maximal insulin response became supranormal at 8 weeks (1.37?±?0.27 vs controls 1.15?±?0.18 nmol min). Pancreatic triacylglycerol decreased from 8.0?±?1.6% to 6.2?±?1.1%.

Conclusions: Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone. This was associated with decreased pancreatic and liver triacylglycerol stores. The abnormalities underlying type 2 diabetes are reversible by reducing dietary energy intake.

Population response to information on reversibility of Type 2 diabetes.

Steven S1, Lim EL, Taylor R.

Diabet Med. 2013 Apr;30(4):e135-8.

Following publication of the Counterpoint Study (on the reversibility of Type 2 diabetes using a very low energy diet), the extent of public interest prompted the authors to make available, on a website, general information about reversing diabetes. Shortly thereafter, individuals began to feed back their personal experiences of attempting to reverse their diabetes. We have collated this information on the effects of energy restriction in motivated individuals with Type 2 diabetes that has been achieved outside a research setting.

Results: Self-reported weight fell from 96.7 ± 17.5 kg at baseline to 81.9 ± 14.8 kg after weight loss. Self-reported fasting blood glucose levels fell from 8.3 mmol/l (5.9-33.0) to 5.5 mmol/l (4.0-10.0) after the weight loss period. Diabetes reversal was considered to have occurred in 61% of the population. Reversal of diabetes was observed in 80, 63 and 53% of those with > 20, 10-20 and < 10 kg weight loss, respectively. There was a significant correlation between degree of weight loss and reported fasting glucose levels (Rs -0.38, P = 0.006). Reversal rates according to diabetes duration were: short (< 4 years) = 73%, medium (4-8 years) = 56% and long (> 8 years) = 43%.

Conclusions: These data demonstrate that intentional weight loss achieved at home by health-motivated individuals can reverse Type 2 diabetes. Diabetes reversal should be a goal in the management of Type 2 diabetes.

Three-week Diet-Exercise Study Shows 50 Percent Reversal In Metabolic Syndrome, Type 2 Diabetes

Source: American Physiological Society

Summary: A UCLA study found the Pritikin diet and daily exercise reverses metabolic syndrome and Type 2 diabetes in 50 percent of those with either condition, even without major weight loss. All participants showed significant health benefits after 21 days on the high-fiber, low-fat diet and 45-60 minutes of daily exercise. The results challenge the commonly held belief that individuals must normalize their weight before achieving health benefits.

Rigorous diet can put Type 2 diabetes into remission, study finds

By Catherine Thorbecke

Some people with Type 2 diabetes were able to put the disease in remission without medication by following a rigorous diet plan, according to a study published today in the Lancet medical journal.

"Our findings suggest that even if you have had Type 2 diabetes for six years, putting the disease into remission is feasible," Michael Lean, a professor from the University of Glasgow in Scotland who co-led the study, said in a statement.

The researchers looked at 149 participants who have had Type 2 diabetes for up to six years and monitored them closely as they underwent a liquid diet that provided only 825 to 853 calories per day for three to five months. The participants were then reintroduced to solid food and maintained a structured diet until the end of the yearlong study.

Is Type 2 Diabetes Reversible?

Short answer: Yes. Long answer: It depends – and even when possible, it may be a tall order.

By Vanessa Caceres and Michael O. Schroeder

Increasingly research finds that in some instances diabetes may be reversed, or – to use the parlance more commonly associated with cancer – a person may be able to achieve remission. That is, in some people previously diagnosed with diabetes, their blood sugar is now back in a non-diabetic range without medication.

That's exactly what happened for more than one-third (36%) of participants randomly assigned to a weight management program, according to a two-year follow-up of a trial published in The Lancet Diabetes & Endocrinology in March.

The most recent follow-up of the Diabetes Remission Clinical Trial, or DiRECT, assessing the impact of intensive weight management in primary care concluded, "Sustained remission was linked to the extent of sustained weight loss." Nearly half (or 46%) of those in the intervention group had achieved and sustained remission at one-year, according to previous follow-up research published in The Lancet in 2018. The research involved individuals 20 to 65 years old who'd had diabetes for less than six years at the outset of the study.

"It's not impossible at all to reverse diabetes," says Dr. Peter Arvan, chief of the division of metabolism, endocrinology and diabetes at the University of Michigan. Certainly, though, experts are quick to point out that often what it takes to do so, such as wholesale changes to completely alter the way one eats and shifting one's schedule to prioritize exercise, can be challenging to say the least.

"It does look like duration makes a difference," says Dr. Louis Philipson, a professor of medicine and director of Kovler Diabetes Center at the University of Chicago and president of medicine & science for the American Diabetes Association.

"If you get prediabetes or you're on the cusp of a diabetes diagnosis, there are ways to eliminate diabetes. But there's no easy cure or magic pill," says certified diabetes educator Anna Simos, a diabetes education and prevention program manager at Stanford Health Care in Stanford, California.

Certified diabetes educator Anna Simos, a diabetes education and prevention program manager at Stanford Health Care in Stanford, California, has seen the most success when patients make a commitment to changing their behaviors and when they find support from both their community, such as through the Centers for Disease Control and Prevention's National Diabetes Prevention Program, and their medical team.

The U.S. government's study of the Diabetes Prevention Program found that in 3,000 people who had prediabetes, those who lost 5% to 7% of their body weight reduced their risk of developing Type 2 diabetes by 58%. The numbers were even more impressive in those over age 60. All study participants were overweight and had high blood sugar.

The participants reversed their prediabetes with increased physical activity, healthier eating and behavior changes. Their results were better than another group in the study that used the common diabetes drug metformin.

Even 10 years later, those who participated in the program were one-third less likely to develop diabetes, according to the CDC. Usually, an estimated 15 to 30 percent of people with prediabetes develop Type 2 diabetes over five years, according to the agency. That risk increases even more over time.

80% of Diabetics Can Reverse Their Disease – Here’s How

Presented by: Tufts Medical Center

Michael Dansinger, MD, who is known for his role as the nutrition doctor for NBC’s The Biggest Loser and serves as Director of the Diabetes Reversal Program at Tufts Medical Center says most patients can reverse their diabetes by following seven simple tips

(1) Believe it's possible; (2) Use food as medicine (3) Choose a balanced diet; (4) Start a diary; (5) Get a diabetes health coach; (6) get moving; and, (7) Optimize environment.

Could a change of diet reverse diabetes?

By Jerome Burne

All doctors advise using diet to help lower blood sugar, but what makes the new claim so controversial is the idea that the right sort of diet can actually reverse diabetes, cutting out the need for drugs altogether.

One of the leading proponents of the new dietary approach is Dr Fedon Lindberg, a Norwegian endocrinologist who has treated more than 18,000 diabetic patients in his four clinics in his home country.

"My experience with type 2 diabetic patients is that a balanced low-glycaemic diet coupled with a healthy lifestyle can reverse the disease," he says.

"We have had many patients coming to us who were injecting high doses of insulin, as many as 200 units daily, who have managed to quit insulin and come off medications for blood pressure and other conditions."

Another doctor also claiming dramatic success using diet to treat diabetes is Dr Neal Barnard, an American expert whose book, Reversing Diabetes, was published in the UK last week.

"We've run trials showing that a diet with zero animal fats can control blood sugar three times more effectively than the diet recommended by the American Diabetes Association," he says.

Type 2 diabetes can be reversed, say Canadian researchers

Adult-onset, or Type 2, diabetes has long been considered a chronic disease that lasts a lifetime, but Canadian researchers believe they may have found a way to actually reverse the disease, putting it into remission.

 “We used to think that diabetes is irreversible and a progressive disease,” study author Natalia McInnes told CTV News Channel. “This new research suggests that it’s possible to reverse it.”

The research team, from McMaster University in Hamilton, Ont., says an aggressive combination of a low-calorie diet, consistent exercise and the addition of several diabetes medications appears to have reversed the disease in some patients.

Three months later, 11 out of 27 participants in the 16-week program group met the criteria for complete or partial diabetes remission. Those in the eight-week program didn’t fare as well; only six out of 28 participants in that group met the same criteria. But they still fared better than the third group: among those 28 participants, only four were able to put their diabetes into remission.

The full results of the study appear in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Piloting a Remission Strategy in Type 2 Diabetes: Results of a Randomized Controlled Trial

Natalia McInnes, Ada Smith, Rose Otto, Jeffrey Vandermey, Zubin Punthakee, Diana Sherifali, Kumar Balasubramanian, Stephanie Hall, Hertzel C. Gerstein

The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 5, 1 May 2017, Pages 1596–1605

Results: At 8 weeks, 50.0% of the 8-week intervention group vs 3.6% of controls achieved normoglycemia on therapy, and at 16 weeks, these percentages were 70.4% in the 16-week group and 3.6% in controls. Twelve weeks after completion of the intervention, 21.4% of the 8-week group compared with 10.7% of controls and 40.7% of the 16-week group compared with 14.3% of controls met hemoglobin A1C criteria for complete or partial diabetes remission.

Conclusions: A short course of intensive lifestyle and drug therapy achieves on-treatment normoglycemia and promotes sustained weight loss. It may also achieve prolonged, drug-free diabetes remission and strongly supports ongoing studies of novel medical regimens targeting remission.

Type 2 diabetes can be reversed in just four months by cutting calories, exercising and keeping glucose under control, a trial has shown.

By  Sarah Knapton, science editor

Although the condition is considered to be chronic, requiring a lifetime of medication, Canadian researchers proved it was possible to restore insulin production for 40 per cent of patients.

The treatment plan involved creating a personalised exercise regime for each trial participant and reducing their calories by between 500 and 750 a day. The participants also met regularly with a nurse and dietician to track progress and continued to take medication and insulin to manage their blood sugar levels.

After just four months, 40 per cent of patients were able to stop taking their medication because their bodies had begun to produce adequate amounts of insulin again.

The researchers at McMaster University in Ontario, Canada, said the programme worked because it gave the insulin-producing pancreas ‘a rest.’

"The research might shift the paradigm of treating diabetes from simply controlling glucose to an approach where we induce remission and then monitor patients for any signs of relapse," said the study's first author, Dr Natalia McInnes, of McMaster.

"The idea of reversing the disease is very appealing to individuals with diabetes. It motivates them to make significant lifestyle changes.

Emily Burns, the research communications manager of Diabetes UK said: “We know that diet, exercise and medications can help people with Type 2 diabetes to manage their condition. We’re starting to see mounting evidence that putting Type 2 diabetes into remission is feasible as well.”

Naveed Sattar, a professor of metabolic medicine at the University of Glasgow, said: "We know now that intensive diet changes – with calorie restriction over period of few weeks to few months can reverse diabetes in many patients but what we need to determine are ways to keep the weight off and keep people in diabetes 'remission'.

"What happens with weight loss per se is that fat is sucked out of key organs relevant to the efficient metabolism of sugar so this means liver, muscles and pancreas lose fat and start to restore their normal functions leading to lower sugar levels.  

The research was published in the Journal of Clinical Endocrinology & Metabolism (

Type 2 diabetes: Can it be reversed? Doctor's tips on how to put diabetes into remission

TYPE 2 diabetes is regarded a lifelong condition, but research has shown it can sometimes go into remission, while there are claims it can be reversed. But is this actually true? Can type 2 diabetes be reversed? One doctor explains.

By Karolina Kaminska

According to Dr Zenon Andreou, GP at European Online Doctor Zava, it is possible for type 2 diabetes to go into remission for some people, through weight loss and healthy lifestyle choices.

The doctor notes, however, that there is currently no long-term evidence to prove this is a permanent cure.

 “Diets high in refined carbohydrates such as pasta, white bread and sugary drinks raise blood glucose levels and the body’s normal response is to produce more insulin to balance that,” said Dr Zenon.

However, people who have diabetes are unable to create that balance so need to take medication to control it.

But eating healthily and losing weight have helped some people to put their diabetes into remission by reducing blood sugar levels naturally.

 “By reducing the amount of carbohydrates eaten and controlling calorie intake, the body’s blood sugar levels can remain at normal levels and for some diabetics, coupled with ongoing weight loss and exercise, this means that medication is no longer needed,” said Dr Zenon.

 “It is important to note here that we cannot call this a cure, we do not currently have long-term evidence to suggest this is a permanent situation,” he warned.

A Prescription for a Plant-Based Diet Can Help Reverse Diabetes

As worrisome as the new statistics are, the solutions to the diabetes epidemic are at hand. With a plant-based diet, we could help tackle the disease once and for all.

Combining the results of six prior studies, we found that a plant-based diet boosts blood sugar control considerably. Among the studies analyzed was our 2006 NIH-funded trial, which found that plant-based diets could improve a key indicator of blood sugar control called hemoglobin A1c as much as 1.2 points in 22 weeks.

Doctors at Kaiser Permanente, the largest managed care organization in the United States, recently recommended that every patient receive information on plant-based diets.

Neal Barnard, M.D., President of the Physicians Committee for Responsible Medicine

Diabetes Reversal by Plant-Based Diet

Biswaroop Roy Chowdhury, Medical Nutritionist, Indo-Vietnam Medical Board, India

J Metabolic Synd 2017, Vol 6(4): 232.

Findings of the study: The study reported controlled* blood glucose levels for 84% of patients and partially controlled* levels for 16% of patients. Those with controlled* levels could attain a healthy blood glucose range without medicines and or insulin, along with the prescribed diet in 3-days. Those with partially controlled* levels could attain a healthy blood glucose range with less than 50% of insulin than prescribed earlier.

In addition of the insulin-dependent group, 59% could completely drop their insulin requirements and 41% could reduce the requirement to at least 50%. The weight reduction for 55 patients in 3-days was reported as 1.14 kgs of average weight loss per individual. Also, the patients had symptomatic relief from general fatigue and weaknesses. The plant-based diet proved to be beneficial with regards to energy and nutritional fulfillments.

Piloting a Remission Strategy in Type 2 Diabetes: Results of a Randomized Controlled Trial

Natalia McInnes, Ada Smith, Rose Otto, Jeffrey Vandermey, Zubin Punthakee, Diana Sherifali, Kumar Balasubramanian, Stephanie Hall, Hertzel C. Gerstein

The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 5, 1 May 2017, Pages 1596–1605

Results: Twelve weeks after completion of the intervention, 21.4% of the 8-week group compared with 10.7% of controls and 40.7% of the 16-week group compared with 14.3% of controls met hemoglobin A1C criteria for complete or partial diabetes remission.

Conclusions: A short course of intensive lifestyle and drug therapy achieves on-treatment normoglycemia and promotes sustained weight loss. It may also achieve prolonged, drug-free diabetes remission and strongly supports ongoing studies of novel medical regimens targeting remission.

A New Medical Trial Has Seen Type 2 Diabetes "Reversed" in 40% of Patients for 3 Months

Peter Dockrill

To investigate whether intensive health treatments could trigger remission in type 2 diabetes patients, the researchers recruited 83 participants with the condition and randomly divided them into three groups.

Three months after the experiment, 11 out of 27 patients in the 16-week intervention group showed complete or partial diabetes remission, as did six out of 28 individuals in the eight-week group.

But new research suggests that people may actually be able to beat the disease for set periods, by undertaking an intensive short-term course of medical treatment that's been shown to reverse type 2 diabetes in a significant proportion of patients.

"By using a combination of oral medications, insulin, and lifestyle therapies to treat patients intensively for two to four months, we found that up to 40 percent of participants were able to stay in remission three months after stopping diabetes medications," says one of the researchers, Natalia McInnes from McMaster University in Canada.

"The findings support the notion that type 2 diabetes can be reversed, at least in the short term – not only with bariatric surgery, but with medical approaches."

"If you don't sustain the lifestyle intervention, then the disease is going to come back," endocrinologist Philip Kern from University of Kentucky, who wasn't involved with the study, told Health Day News.

Type 2 Diabetes Can Be Reversed Even Without Intensive Weight Loss, Study Shows

Peter Dockrill

In recent years, research has shown that it's possible to reverse a type 2 diabetes diagnosis and send the disease into remission, and now a new study demonstrates that recovering from the disease could be a lot easier than you think.

"We've known for some time now that it's possible to send diabetes into remission using fairly drastic measures such as intensive weight loss programmes and extreme calorie restriction," says epidemiologist Dr.Hajira Dambha-Miller from the the University of Cambridge.

But according to Dambha-Miller, people with type 2 diabetes may not need to go quite so extreme to increase their chances of reversing the condition.

"Our results suggest that it may be possible to get rid of diabetes, for at least five years, with a more modest weight loss of 10 percent," Dambha-Miller says.

In the new study, the researchers examined a cohort of 867 people aged between 40 and 69 years who were newly diagnosed with type 2 diabetes.

Ultimately, at the end of five years of follow-ups, 257 of the participants (about 30 percent of the whole cohort) were in remission.

The findings are reported in Diabetic Medicine (

2 Nurses In Tennessee Preach 'Diabetes Reversal'

Steve Wickham, at home in Grundy County, Tenn., has developed an educational seminar with his wife, and fellow nurse, Karen, that they are using to help people with Type II diabetes bring blood sugar under control with less reliance on drugs.

Steve and Karen Wickham explain course materials to participants in their seminar on Type 2 diabetes in Grundy County, Tenn. The six-week seminar offers detailed instruction on the biology of diabetes, diet and exercise — and provides plenty of individualized support.

Type 2 diabetes can be reversed with weight loss and exercise; but research shows that people need lots of help to achieve control of blood sugar with just a change in diet and lifestyle, and they rarely get enough support. It's easier for doctors and patients to rely primarily on medication.

Type 2 diabetes is a reversible condition

Source: Newcastle University

Date: September 13, 2017

Summary: People with type 2 diabetes can reverse the condition through a low calorie diet.

A body of research putting people with Type 2 diabetes on a low calorie diet has confirmed the underlying causes of the condition and established that it is reversible.

Professor Roy Taylor at Newcastle University, UK has spent almost four decades studying the condition and will present an overview of his findings at the European Association For The Study Of Diabetes (EASD 2017) in Lisbon.

This reversal of diabetes remains possible for at least 10 years after the onset of the condition

The body of research by Professor Roy Taylor now confirms his Twin Cycle Hypothesis -- that Type 2 diabetes is caused by excess fat actually within both liver and pancreas.

"The good news for people with Type 2 diabetes is that our work shows that even if you have had the condition for 10 years, you are likely to be able to reverse it by moving that all important tiny amount of fat out of the pancreas. At present, this can only be done through substantial weight loss," Professor Taylor adds.

After the details were posted on the Newcastle University, UK website, this has been applied clinically and people who were highly motivated have reported that they have reversed their type 2 diabetes and continued to have normal glucose levels (normoglycaemic) over years.

A further study in general practice, the Diabetes Remission Clinical Trial (DiRECT) funded by Diabetes UK is now underway to determine the applicability of this general approach to routine Primary Care practice with findings due before the end of the year.

Science News: Reverse your diabetes: You can stay diabetes-free long-term

Date: March 22, 2016
Source: Newcastle University

A new study from Newcastle University has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes. In addition, the team found that even patients who have had Type 2 diabetes for up to 10 years can reverse their condition.

The study, published in Diabetes Care, is the latest research from Professor Roy Taylor, Professor of Medicine and Metabolism at Newcastle University, who also works within Newcastle Hospitals.

Reversal of type 2 diabetes via normalization of beta cell function. Diabetologia. 2011 Oct;54(10):2477-9.
A ground breaking new study in Diabetologia proved that Type 2 diabetes can be reversed through diet changes, and, the study showed, this can happen quickly: in one to eight weeks. Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R.

What Foods to Eat to Reverse Diabetes

Medical Editor: Erica Oberg, ND, MPH  Medical Editor: Jerry R. Balentine, DO, FACEP

Doctor’s Response

Not all people with diabetes need drug therapy. A healthy eating plan and exercise alone can be enough if the person makes significant lifestyle changes. This health condition can be prevented by following a low glycemic load diet (basically, a diet low in sugars), staying physically active, and getting regular medical screenings.

If you have this type of diabetes the foods you eat should have a low glycemic load (index) (foods higher in fiber, protein or fats) like vegetables and good quality protein such as fish, chicken, beans, and lentils. From that base, other types of nutritious foods like fruit, whole grains, low-fat dairy products, and nuts should be added.

Foods with a high glycemic index (foods that raise blood sugar too quickly) are foods to avoid, such as processed foods, high in carbohydrates, sugars, or animal fat

Intake of different dietary proteins and risk of type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

Heli E. K. Virtanen, Timo T. Koskinen, Sari Voutilainen, Jaakko Mursu

British Journal of Nutrition

We investigated the associations of dietary proteins with the risk of incident T2D in Finnish men from the prospective Kuopio Ischaemic Heart Disease Risk Factor Study. The study included 2332 men aged 42–60 years at the baseline examinations in 1984–1989.

Replacing 1 % of energy from animal protein with energy from plant protein was associated with 18 % (95 % CI 0, 32) decreased risk of T2D. This association remained after adjusting for BMI. In conclusion, favouring plant and egg proteins appeared to be beneficial in preventing T2D.

Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin.

Furmli S, Elmasry R, Ramos M, Fung J.

Summary: This case series documents three patients referred to the Intensive Dietary Management clinic in Toronto, Canada, for insulin-dependent type 2 diabetes.

Conclusions: It demonstrates the effectiveness of therapeutic fasting to reverse their insulin resistance, resulting in cessation of insulin therapy while maintaining control of their blood sugars. In addition, these patients were also able to lose significant amounts of body weight, reduce their waist circumference and also reduce their glycated haemoglobin level.

More people need to know type 2 diabetes is reversible' argues report

National Health Service - UK

What is the issue?

"Type 2 diabetes could be beaten into remission if patients shed around 15kg, [2.4 stones]," reports BBC News. In the past type 2 diabetes was thought to be a lifelong condition. There is increasing evidence that even if it can't be cured, it is possible to put the condition into remission through weight loss.

A pressing problem is, as The Daily Telegraph reports, that "less than 1 in 1,000 people" achieve remission.

Achieving weight loss through a combination of diet and exercise could mean that you do not have to start taking medication for type 2 diabetes.

What is diabetes remission?

In recent years, doctors have noticed that some obese patients who lose a lot of weight, whether through very low calorie diets or weight loss surgery, have blood sugar levels that drop back to normal, and stay that way without diabetes medicines. This has fueled interest in "reversing" diabetes through major weight loss.

Instead of curing diabetes, doctors talk about diabetes being "in remission". This is because it can be a two-way process – if people put weight back on, they may become diabetic again.

They recommend remission is defined when there are two blood sugar measurements of less than 6.5%HbA1c, at least two months apart, when the patient has not taken diabetes medicines for at least two months.

Mainstream media admits diabetes can be reversed through major diet, lifestyle changes
Monday, February 07, 2011 by: Ethan A. Huff, staff writer

(NaturalNews) The mainstream media is just now catching on to what NaturalNews and other natural health advocates have been saying for years: type 2 diabetes can be reversed through dietary and lifestyle changes, and without the need for lifelong drug interventions.

A recent report by CNN says that improving one's diet, keeping off excess weight, and regularly exercising, can help millions of people with diabetes get rid of it for good.

Mercy Medical Center Endocrinologist Dr. Amber Taylor: Type 2 diabetes can be reversed with lifestyle changes: Eating more vegetables, more grains and fiber, exercise

The Centers for Disease Control and Prevention calls Type 2 diabetes a growing epidemic in the U.S., as millions of people suffer from it, but the disease is preventable, and doctors said it can be reversed in some cases.

(Watch video)

Type 2 diabetes can be prevented by the adoption of a healthier lifestyle
Sept 2001
In a report in The New England Journal of Medicine, Walter Willett, MD, PhD, and his colleagues from the Harvard School of Public Health demonstrated that 91 percent of all Type 2 diabetes cases could be prevented through improvements lifestyle and diet.
Frank B. Hu, M.D., JoAnn E. Manson, M.D., Meir J. Stampfer, M.D., Graham Colditz, M.D., Simin Liu, M.D., Caren G. Solomon, M.D., and Walter C. Willett, M.D.

N Engl J Med 2001; 345:790-797 September 13, 2001

Engineer proves diabetes is reversible with plant-based diet.
February 21, 2006 Rochester Democrat & Chronicle
Xerox engineer reversed his diabetes and got off insulin by following a strict plant-based diet of vegetables, legumes, fish, and plant oils.
PDF file of newspaper article

Software executive cures himself of diabetes at the age of 30.
Mike Adams, now known as the Health Ranger, cured himself of diabetes in a matter of months and transformed himself into the picture of perfect health in mind, body and spirit. Mike dove into research; he devoured thousands of books on nutrition, pharmaceutical drugs, wellness programs, the politics of food - anything he could find.

Mike has now made it his life mission to share the most remarkable discovery he made on his quest: the vast majority of all diseases can be easily prevented and even cured without drugs or surgery.

The Diabetes Prevention Program study, a very large randomized clinical trial , by Deborah Greenwood, MEd, CNS, BC-ADM, CDE: (the most accurate study design) showed that you could reduce the development of diabetes by 58% by doing some simple things. 1. Lose 5-10% of your body weight by eating healthy, with calorie and fat reduction (only 25% of calories from fat). 2. Engage in physical activity for at least 30 minutes five times per week.

These changes can significantly reduce the risk of developing diabetes. Other studies have looked at other types of weight loss such as using meal replacements. The global consensus is that if you lose weight and keep it off, you may be able to prevent diabetes as well as improve blood pressure and lab values.

Simply Raw: Reversing Diabetes in 30 Days is an independent documentary film that chronicles six Americans with diabetes who switch to a diet consisting entirely of vegan, organic, live, raw foods in order to reverse diabetes naturally.
A medical team was established to monitor various health variables of the subjects. The diet: "No meat, no dairy, no alcohol, no caffeine, no refined foods, no junk food or fast food of any kind, no candies, no sugar".
Conclusion: Type 2 diabetes can be cured, or at least drastically reduce blood sugar, hemoglobin a1c, blood pressure, cholesterol, weight, etc.

Medical research confirms lifestyle change can reverse diabetes
December 21, 1979
Medical research confirms that up to 50% of people with Type 2 diabetes can eliminate diabetes risks and discontinue medication within three weeks by adopting a low-fat, plant food diet and regular daily exercise.

Anderson, JW and Ward, K: High Carbohydrate, High fiber diets for insulin-treated men with diabetes mellitus. Am J Clin Nutr, 1979; 32:2312-21.

Regression of Diabetic Neuropathy with Total Vegetarian (Vegan) Diet

Milton G. Crane &Clyde Sample

This study reports alleviation of the sharp, burning pains characteristic of systemic distal polyneuropathy (SDPN) patients with adult-onset (Type II) diabetes mellitus (AODM).

Complete relief of the SDPN pain occurred in 17 of the 21 patients in 4 to 16 days. The numbness persisted, but had noticeably improved. Weight loss averaged 4-9 ± 2-6 kg during the 25 days. By the 14th day, the fasting blood glucose level averaged 35% lower for the 11 patients who were above 6-6 mmoll1, and the insulin needs had dropped in half the patients. Five no longer needed hypoglycemic agents. Also, serum triglyceride and total cholesterol had decreased by 25-0 ± 23% and 13 ± 15% respectively (p <0-01) in 2 weeks.

Follow-up studies of 17 of the 21 patients for 1-4 years indicated that 71% had remained on the diet and exercise programme as advised in nearly every item. In all except one of the 17 patients, the relief from the SDPN had continued, or there was further improvement.

Note: For more studies and references about nutrition, supplements and diabetes, refer to our Clinical Studies web page.

Next Steps to Reverse Type 2 Diabetes

If you want to prevent or reverse your diabetes into remission, then, obtain one or more of the following of the author's books, which address Type 2 diabetes and its root causes:

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