Sexual dysfunction -- it's the disorder no one wants to talk about, yet according to the Journal of the American Medical Association, 43% of men and 31% of women suffer from some form of sexual dysfunction.

Sexual dysfunction is broadly defined as the inability to fully enjoy sexual intercourse. Men experience it as impotence -- it's known technically as erectile dysfunction or ED for short. Women generally experience sexual dysfunction as a loss of libido (sexual drive) and/or the inability or difficulty in achieving an orgasm.   

With the escalating rises in heart disease, Type 2 diabetes, obesity, and high blood pressure, erectile dysfunction (ED, impotence) has risen exponentially such that more than 40 million men in the United States and 257 million men worldwide are affected.

Unfortunately, because of the popularity and effectiveness of ED drugs such as Viagra, Cialis and Levitra, the ED problem has gone "underground" and is being overlooked as a key indicator of impending heart disease and potential heart attacks and strokes.

In addition, what most men don't realize is that eventually the ED drugs lose their effectiveness and they're right back where they started -- with an embarrassing problem and no real solutions.

And, in some cases, they're worse off, because of the damage that these drugs cause to the circulatory system and other parts of the body, e.g. blindness, kidney failure, heart attack, stroke, paralysis.

In the case of women, sexual dysfunction is not addressed either because most women are not clinically diagnosed or they  have learned to live with the problem.  

Recent epidemiologic studies suggest that approximately 10% of men aged 40-70 have severe or complete erectile dysfunction, defined as the total inability to achieve or maintain erections sufficient for sexual performance.

An additional 25% of men in this age category have moderate or intermittent erectile difficulties. The disorder is highly age-dependent, as the combined prevalence of moderate to complete erectile dysfunction rises from approximately 22% at age 40 to 49% by age 70.

Although less common in younger men, erectile dysfunction still affects 5%-10% of men below the age of 40. Findings from these studies show that erectile dysfunction impacts significantly on mood state, interpersonal functioning, and overall quality of life.

It is estimated that at least 40 million American men have erectile dysfunction, and 70% of cases are a result of a potentially deadly condition like atherosclerosis, kidney disease, vascular disease, neurological disease, or diabetes.

A study in the Journal of the American Geriatrics Society found that about 49% of men ages 40 to 79 with high blood pressure had erectile dysfunction. 

Additionally, ED can also be caused by certain medications, surgical injury, and psychological problems.

Given the increase in health problems such as heart disease, diabetes, high blood pressure, and obesity that cause damage to the cardiovascular system, it's not a surprise that there is an increase in health issues such as erectile dysfunction (ED) in men and sexual dysfunction in women.

These sexual health problems are primarily due to the damage to the artery walls (endothelium layer) which cause insufficient blood flow and poor arterial/venous circulation created by many years of poor eating habits, a sedentary lifestyle, fatigue, and stress.

In fact, one in 10 men will suffer from ED at some point in their lives. Because of the connection to manhood, erectile dysfunction poses a serious problem to a man's self esteem.

Among the major risk factors associated with ED are Type 2 diabetes, heart disease, hypertension, obesity and decreased HDL levels. Medications for diabetes, hypertension, cardiovascular disease and depression may also cause erectile difficulties.

The association between cardiovascular disease and erectile dysfunction has been recognized and well documented. Indeed, alterations in the vascular hemodynamics (whether, arterial insufficiency or endothelial dysfunction) is believed to be the most common cause of organic erectile dysfunction.

Such vascular disease as myocardial infarction, coronary artery bypass surgery, cerebral vascular accidents, peripheral vascular disease and hypertension have all been shown to have a higher incidence of impotence compared to the general population without documented vasculopathies.

Myocardial infarction (MI) and coronary artery bypass surgery have been associated with erectile difficulties in 64% and 57% respectively. Furthermore, in a group of 130 impotent men, the incidence of MI was 8 times higher in men with abnormal penile-brachial indices (PBI) than those with normal PBI (12% vs 1.5%). In men with peripheral vascular disease (PVD), the incidence of erectile dysfunction has been estimated at 80%.

In addition, there is a higher prevalence of erectile dysfunction among men who have undergone radiation or surgery for prostate cancer, or who have a lower spinal cord injury or other neurological diseases (e.g. Parkinson’s disease, multiple sclerosis).

Life style factors, including smoking, alcohol consumption and a sedentary lifestyle are additional risk factors.

The psychological correlates of erectile dysfunction include anxiety, depression and anger. Despite its increasing prevalence among older men, erectile dysfunction is not considered a normal or inevitable part of the aging process. 

As depicted in the following diagram, some of the risk factors that contribute to erectile dysfunction (ED) and cause damage to the small blood vessels and arteries include chronic inflammation, heart disease, obesity, diabetes, high homocysteine, high CRP, high cholesterol, high triglycerides, high blood pressure (hypertension), oxidative stress, obesity, and nutrient deficiencies.

Other risk factors associated with ED include genetics, age, diet, lifestyle and ethnicity.

Cardiovascular-Disease-Risk-Factors-Death-to-Diabetes

High blood pressure is a major cause of erectile dysfunction. A study in the Journal of the American Geriatrics Society found that about 49% of men ages 40 to 79 with high blood pressure had erectile dysfunction. 

A more recent study of men with high blood pressure, published in the Journal of Urology in 2000, found that 68% of them had some degree of erectile dysfunction. For 45% of the men, it was considered severe.

High blood pressure keeps the arteries that carry blood into the penis from dilating the way they're supposed to. It also makes the smooth muscle in the penis lose its ability to relax. As a result, not enough blood flows into the penis to make it erect.

Men with high blood pressure may also have a low testosterone level. Testosterone is the male hormone that plays a big role in sexual arousal.

High blood pressure by itself can lead to erectile dysfunction especially if you are clogging your arteries with processed foods, fast foods, fried foods, other high fat foods, and excess animal meat.

In addition, some drugs that are prescribed for treating high blood pressure can actually cause erectile dysfunction as well.

Diuretics -- or water pills -- and beta-blockers are the high blood pressure drugs most commonly linked to erectile dysfunction.

Diuretics may cause erectile dysfunction by decreasing the force of blood flow into the penis. They may also decrease the amount of zinc in the body. Your body needs zinc to make testosterone.

Beta-blockers dampen the response to nerve impulses that lead to an erection. They also make it more difficult for the arteries in the penis to widen and let in blood. What's more, they can make you feel sedated and depressed -- and the mind always plays some part in sexual arousal.

Sometimes, the choices that some men with high blood pressure make can add to the problem. Smoking, especially, is one of those. Smoking increases blood pressure, and damages blood vessels and reduces blood flow all around the body. Drinking too much alcohol can also be a major contributor.

The power to take control of your blood pressure and your sexual health is in your hands. By changing your diet (to plant-based) and by living a healthy lifestyle (with consistent exercise, less stress, and quality sleep), there's a chance you'll once again be able to have normal sexual function.

The good news is that since the majority of ED cases is due to cardiovascular issues, then, ED can be best addressed with dietary changes and nutritional supplements that improve the cardiovascular system and endothelial function.

Key Point: The real key to successfully treating ED is to determine what is causing the ED; and, then, treat the cause instead of the symptoms. Unfortunately, because of the popularity of the ED drugs, most men prefer the quick fix instead of trying to figure out what is actually causing the problem.

For example, depending on whether the cause is biochemical, hormonal, physical, or psychological will determine the best treatment strategy.

A set of effective nutritional and wellness strategies should focus on reducing the effects of biological processes such as high blood pressure, high cholesterol, high blood sugar, excess weight gain (belly fat), chronic inflammation, oxidative stress, excess glycation, etc. while reducing plaque formation and improving endothelial function.

A well-designed nutritional program should target specific nutritional deficiencies that address endothelial dysfunction, obesity, nutrient deficiencies, and address other circulatory issues without the need for drugs.

The 4 major natural remedies and treatment strategies for ED include the following:

  • Nutritional Strategies
  • Nutritional Supplementation Strategies
  • Lifestyle Strategies
  • Medical Strategies

These strategies can be used separately or you can use a combination of them, based on your specific health needs.

"Super" Foods: Start a nutritional program that nourishes the cardiovascular system, especially the arteries and the thickness of the blood, e.g. vegetables, fruits, legumes, nuts, seeds, plant oils, etc.

To nourish and protect the cardiovascular system, eat green and bright-colored vegetables such as spinach, kale, broccoli, red peppers, and pumpkin for the Vitamin C, chlorophyll, folate.

Eat carotenoid-rich foods such as red peppers, tomatoes, carrots, pumpkin, and cantaloupe to inhibit the formation of LDL cholesterol.

Eat heart-healthy fats such as avocado, cold-water fish (wild salmon, sardines), and use extra virgin olive oil for the Omega-3s/ monounsaturated fats and to increase absorption of the fat-soluble carotenoids.

Also, eat folate-rich foods such as spinach and lima beans to reduce homocysteine and prevent arterial plaque formation.

Eat foods that help to release nitric oxide that (along with l-arginine) helps to relax the artery walls, e.g. beets, cayenne pepper, garlic, onions, spinach, and walnuts.

Also, consider taking a proteolytic enzyme such as serrapeptase to help break down fibrous proteins associated with arterial plaque and damaged endothelial lining of the artery walls.

Eat foods and nutrients that nourish and protect and the heart and the cardiovascular system, e.g. celery, tomatoes, CoQ10, cayenne, ginger, onions, and garlic.

Raw Juicing: Drink 6 to 8 oz. raw vegetable juice 30 minutes before breakfast and dinner.

"Dead" Foods: avoid the refined and processed foods, especially bread, pasta, rice, potatoes, trans fats, soda, etc.

Smoking and Alcohol: Stop smoking and drinking too much alcohol since nicotine and alcohol cause major damage to the cardiovascular system.

The following is a list of various nutrients and supplements that have been identified in various studies to help with ED. 

Açai berries: are rich in oleic acid, which helps Omega-3 fish oils penetrate the cell membrane, making them more supple.

Arginine: is an amino acid that increases the production of nitric oxide to relax artery walls. Foods rich in the arginine include fish, poultry, dairy, nuts, and dark chocolate. Take with citrulline on an empty stomach for optimum absorption and effectiveness.

Astragalus: strengthens the beating and contraction of the heart, while increasing the level of energy production within heart cells.

Beet juice/powder: contains nitrates, which are converted into nitric oxide, which helps to relax and dilate your blood vessels, improving blood flow and lowering your blood pressure.

Beet juice is a good source of folate and betaine. These nutrients act together to help lower homocysteine, which can increase your risk of heart disease by causing artery-damaging inflammation.

Betaine: is a natural polysaccharide found in beets that can lower homocysteine levels.

Bilberry: is a bioflavonoid with active ingredients similar to those found in grapes and black currants including anti-inflammatory factors, anti-clotting factors, and several properties which result in a collagen-stabilizing effect. This effect strengthens the veins by restoring the surrounding connective tissue sheath, decreasing their fragility and permeability. This helps to prevent blood pooling, clotting, and swelling that can lead to varicose veins and other venous conditions.

Cayenne pepper (capsicum): acts as a circulatory stimulant that produces a speedy reaction in the circulatory system, removing the obstructions by natural evacuations and profuse perspiration; and, helps the arteries, veins and capillaries to regain their elasticity, causing blood pressure to adjust itself to normal.

Cayenne regulates the flow of blood from the head to the feet so that the pressure is equalized. It influences the heart immediately, and then gradually extends its effects to the arteries, capillaries, and nerves (the frequency of the pulse is not increased, but is given more vigor). In equalizing the blood circulation, cayenne produces natural warmth; and in stimulating the peristaltic motion of the intestines, it aids in assimilation and elimination.

Citrulline: is an amino acid that escapes presystemic metabolism and is converted to larginine, thus setting up as a donor for the l-arginine/nitric oxide pathway of penile erection.

Garlic: contains allicin, which enables red blood cells to release hydrogen sulfide to relax artery walls; inhibits red blood cells from sticking together; and, helps break down the buildup of plaque in the arterial walls. Similar to Vitamin E, onions, ginger, and Omega-3s, garlic helps to thin the blood.

Ginger: is known as the “poor man’s aspirin”. Ginger thins the blood, lowers cholesterol and increases blood circulation to help prevent strokes and hardening of the arteries, based on research done at Cornell University Medical College. 

Ginger improves and stimulates circulation and relaxes the muscles surrounding blood vessels, facilitating the flow of blood throughout the body. As a circulatory stimulant (for the extremities), it works well with cayenne pepper, a circulatory stimulant (for the heart).

Ginkgo biloba: contains flavonoids, including quercetin. Gingko acts as an antioxidant, anti-allergen, anti-inflammatory; and, as an oxygen-carrying agent, it increases the blood flow throughout the circulatory system as well as the brain. It may reduce plaque that builds up around artery walls. Ginkgo biloba has been used in the treatment of early-stage Alzheimer’s disease, vascular dementia, and peripheral claudication.

Warning: Ginkgo can increase the risk of bleeding if used in combination with warfarin or antiplatelet agents.

Grapeseed extract: contains a concentration of the oligomeric proanthocyanidins (OPCs) found in grape seeds and skins that acts as a smooth muscle relaxant in blood vessels, to combat hypertension. It provides nutrient support to strengthen the walls of small capillaries to prevent capillary leakage in the legs, reducing fluid retention. 

Pycnogenol: is a phytonutrient extract taken from French maritime pine bark, that contains oligomeric proanthocyanidins (OPCs), a group of powerful antioxidant compounds commonly found in grape seed extract.

OPCs, also called procyanidolic oligomers (PCOs), have anti-inflammatory, antioxidant, antiviral and antimicrobial properties that stimulate your immune system, protect against atherosclerosis and prevent certain types of cancers, according to the Sloan-Kettering.

Specifically, the OPCs in pine bark extract (pycnogenol) make blood vessels more elastic and less likely to leak fluids, thus decreasing the leg swelling often associated with varicose veins.

In addition, the flavonoids called catechin and taxifolin in pycnogenol stimulate nitric oxide production in the body, which relaxes your blood vessels and lowers your blood pressure.

A study from the University of Arizona Medical School and the University of Munster, Germany, demonstrated that pycnogenol significantly reduces platelet aggregation—the clumping together of blood cells to form blood clots that cut off blood flow and precipitate heart attacks and strokes.

More recent research found that pycnogenol also helps enhance the production of nitric oxide, a molecule made by the endothelial cells lining the arteries that keeps them open and relaxed, which is important for maintaining healthy blood pressure and circulation.

Research has also found that pycnogenol in combination with l-arginine is an effective natural treatment for erectile dysfunction; and, that taking pycnogenol before, during, and after long flights reduces the risk of deep vein thrombosis (DVT).

Other studies have shown pycnogenol to boost the effectiveness of vitamin C and other antioxidants; and, provide cardiovascular and diabetes-related benefits.

Note: Pycnogenol is similar in composition to grape seed extract as it provides a similar benefit in strengthening blood vessels.

WARNING: Because many of these supplements can interact with various heart medications, make sure that you consult with your primary care physician and/or cardiologist before adding any of these supplements to your daily nutritional regimen.

Exercise: Perform consistent aerobic exercise, 4 to 5 times a week, for 30 to 40 minutes to support healthy heart function.

If you are a beginner, exercise for a few minutes each day and build up to 30 minutes. When starting out, you should plan a routine that is easy to follow and stick with. As the program becomes more routine, you can vary your exercise times and activities. 

Stress: Get enough sleep; use yoga/meditation; and, talk to a friend to reduce the stress in your life.

The key to coping with stress is to identify stressors in your life and learn ways to direct and reduce stress. Learning an effective means of relaxation and using it regularly is a good first step. Allow yourself some "quiet time," even if it's just a few minutes.

Talking problems out with a friend or family member can help put things in proper perspective. Seeking professional assistance can help you gain a new perspective on how to manage some of the more difficult forms of stress.

Medical: Ensure that your doctor performs a series of stress tests to better evaluate the health of your heart and cardiovascular system.

Request additional blood tests at least once a year for inflammation markers such as homocysteine, C-reactive protein, lipoprotein (a), fibrinogen.

Check your medications: Some medications can cause ED, including diuretics, antihypertensives, antihistamines, non-steroidal anti-inflammatory drugs, antidepressants, anti-anxiety drugs and antiepileptic drugs.

Refer to the wellness protocol section in Chapter 15 of the Death to Diabetes book and the Power of Juicing ebook for more details about the circulatory system.

Note: If you want to address the underlying biological causes of your erectile dysfunction, (e.g. heart disease, diabetes, high blood pressure, obesity, etc.) then, get one or more of the following books:

Also, take a look at the Death to Diabetes Blog;for more information about ED; and, visit the High Blood Pressure and High Cholesterol web pages for additional natural treatment strategies.

References 

  1. Wu G, Morris SM (November 1998). "Arginine metabolism: nitric oxide and beyond". The Biochemical Journal. 336. ( Pt 1): 1–17. PMC 1219836. PMID 9806879
  2. Morris SM (2002). "Regulation of enzymes of the urea cycle and arginine metabolism". Annual Review of Nutrition 22 (1): 87–105. doi:10.1146/annurev.nutr.22.110801.140547. PMID 12055339
  3. Furuno T, Mullen MJ Thorne SA Thomson H Donald AE Powe A et al. Intravenous L-arginine restores endothelial function in healthy young smokers (abstract). Circulation 1996;94:3052.
  4. Maxwell AJ, Anderson B. A nutritional product designed to enhance nitric oxide activity restores endothelium-dependent function in hypercholesterolemia (abstract). J Am Coll Cardiol 1999;33:282A.
  5. Sofiabadi, M. and Rajaje, F. The Histological Effects of L-arginine on Ventricular Myocardium in Iron Treated Male Rats. Qom University of Medical Sciences Journal 2010;4:10-14.
  6. Tangphao, O., Chalon, S., Moreno, H., Jr., Hoffman, B. B., and Blaschke, T. F. Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia. Clin.Sci.(Lond) 1999;96:199-207. View abstract.
  7. Pezza, V., Bernardini, F., Pezza, E., Pezza, B., and Curione, M. Study of supplemental oral l-arginine in hypertensives treated with enalapril + hydrochlorothiazide. Am.J Hypertens. 1998;11:1267-1270.
  8. Moody JA, Vernet D, Laidlaw S, Rajfer J, Gonzalez-Cadavid NF (September 1997). "Effects of long-term oral administration of L-arginine on the rat erectile response". The Journal of Urology 158 (3 Pt 1): 942–7. doi:10.1016/S0022-5347(01)64368-4. PMID 9258123
  9. Cockcroft JR (Dec 2005). "Exploring vascular benefits of endothelium-derived nitric oxide". American Journal of Hypertension. 18 (12 Pt 2): 177S–183S. doi:10.1016/j.amjhyper.2005.09.001. PMID 16373196
  10. Förstermann U, Sessa WC (Apr 2012). "Nitric oxide synthases: regulation and function". European Heart Journal. 33 (7): 829–37, 837a–837d. doi:10.1093/eurheartj/ehr304. PMID 21890489.
  11. Oliveira-Paula GH, Lacchini R, Tanus-Santos JE (Feb 2014). "Inducible nitric oxide synthase as a possible target in hypertension". Current Drug Targets. 15 (2): 164–74. doi:10.2174/13894501113146660227. PMID 24102471.
  12. Fish JE, Marsden PA (Jan 2006). "Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium". Cellular and Molecular Life Sciences. 63 (2): 144–62. doi:10.1007/s00018-005-5421-8. PMID 16416260.
  13. Sumpio BE, Riley JT, Dardik A (Dec 2002). "Cells in focus: endothelial cell". The International Journal of Biochemistry & Cell Biology. 34 (12): 1508–12. doi:10.1016/s1357-2725(02)00075-4. PMID 12379270.
  14. Förstermann U, Münzel T (Apr 2006). "Endothelial nitric oxide synthase in vascular disease: from marvel to menace". Circulation. 113 (13): 1708–14. doi:10.1161/CIRCULATIONAHA.105.602532. PMID 16585403
  15. Jia Z, Zhang X, Kang S, Wu Y (2013). "Association of endothelial nitric oxide synthase gene polymorphisms with type 2 diabetes mellitus: a meta-analysis". Endocrine Journal. 60 (7): 893–901. doi:10.1507/endocrj.ej12-0463. PMID 23563728
  16. Shoukry A, Shalaby SM, Abdelazim S, Abdelazim M, Ramadan A, Ismail MI, Fouad M (Jun 2012). "Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus". Genetic Testing and Molecular Biomarkers. 16 (6): 574–9. doi:10.1089/gtmb.2011.0218. PMID 22313046.
  17. Taverna MJ, Elgrably F, Selmi H, Selam JL, Slama G (Aug 2005). "The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy". Nitric Oxide. 13 (1): 88–92. doi:10.1016/j.niox.2005.04.004. PMID 15890549
  18. Chen J, Wollman Y, Chermichovsky T, Iaina A, Sofer M, Matzkin H. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU Int 1999; 83: 269–273. 
  19. Klotz T, Mathers MJ, Braun M, Bloch W, Engelmann U. Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urol Int 1999; 63: 220–223. 
  20. Lebret T, Herve JM, Gorny P, Worcel M, Botto H. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol 2002; 41: 608–613. 
  21. Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. Cardiovasc Pharmacol 1998; 32: 509–515. 
  22. Durackova Z, Trebaticky B, Novotny V, Zitnanova A, Breza J. Lipid metabolism and erectile function improvement by Pycnogenol®, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction—apilot study. J Nutr Res 2003; 23: 1189–1198. 
  23. Rohdewald P. Pycnogenol, French maritime pine bark extract. In: Encyclopedia of Dietary Supplements. Marcel Dekker: New York, 2005, pp 545–553.
  24. Hosseini S, Lee J, Sepulveda RT, Fagan T, Rohdewald P, Watson RR. A randomized, double blind, placebo controlled, prospective, 16 week crossover study to determine the role of Pycnogenol® in modifying blood pressure in mildly hypertensive patients. Nutr Res 2001; 21: 67–76. 
  25. Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Pycnogenol®, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 2004; 74: 855–862.
  26. Devaraj S, Vega-López S, Kaul N, Schönlau F, Rohdewald P, Jialal I. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 2002; 37: 931–934.
  27. Koch R. Comparative study of Venostasin® and Pycnogenol® for treatment in chronic venous insufficiency. Phytother Res 2002; 16: 1–5. 
  28. Farid R, Mirfeizi Z Mirheidari M Z Rezaieyazdi Mansouri H Esmaelli H. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research 2007;27:692-697.
  29. Roseff SJ, Gulati R. Improvement of sperm quality by pycnogenol. Eur Bull Drug Res 1999;7:33-36.
  30. Rohdewald P. Reducing the risk for stroke and heart infarction with pycnogenol. Eur Bull Drug Res 1999;7:14-18.
  31. Dvoráková M1, Sivonová M, Trebatická J, Skodácek I, Waczuliková I, Muchová J, Duracková Z. Redox Rep. 2006;11(4):163-72. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD).
  32. S. Iravani1 and B. Zolfaghari, PhD. Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract. Res Pharm Sci. 2011 Jan-Jun; 6(1): 1–11. 
  33. "Male Sexual Dysfunction Epidemiology". Erectile dysfunction. Armenian Health Network, Health.am. 2006. Retrieved 2007-10-07.
  34. Tom F. Lue, MD (2006). "Causes of Erectile Dysfunction". Erectile dysfunction. Armenian Health Network, Health.am. Retrieved 2007-10-07.
  35. "Erectile Dysfunction Causes". Erectile Dysfunction. Healthcommunities.com. 1998. Retrieved 2007-10-07.
  36. Korenman SG (2004). "Epidemiology of erectile dysfunction". Endocrine. 23 (2–3): 87–91. doi:10.1385/ENDO:23:2-3:087. PMID 15146084.
  37. Kendirci M, Nowfar S, Hellstrom WJ (2005). "The impact of vascular risk factors on erectile function". Drugs Today (Barc). 41 (1): 65–74. doi:10.1358/dot.2005.41.1.875779. PMID 15753970
  38. Wespes E (chair), et al. Guidelines on Male Sexual Dysfunction: Erectile dysfunction and premature ejaculation. European Association of Urology 2013
  39. Pourmand G, Alidaee MR, Rasuli S, Maleki A, Mehrsai A (2004). "Do cigarette smokers with erectile dysfunction benefit from stopping?: a prospective study". BJU Int. 94 (9): 1310–3. doi:10.1111/j.1464-410X.2004.05162.x. PMID 15610111
  40. "Dangers of Sexual Enhancement Supplements" http://www.medscape.com/viewarticle/562177
  41. "Neurogenic Sexual Dysfunction in Men and Women" (PDF). Neurologic Bladder, Bowel and Sexual Dysfunction. Retrieved 2015-08-10.
  42. Stanislavov R1, Nikolova V., J Sex Marital Ther. 2003 May-Jun;29(3):207-13. Treatment of erectile dysfunction with pycnogenol and L-arginine. Daily oral administration of L-arginine (1.7 g) in combination with Pycnogenol (120 mg) causes a 92.5% improvement in sexual function in men with ED without any side effects. http://www.ncbi.nlm.nih.gov/pubmed/12851125
  43. Brindley GS (October 1983). "Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence". Br J Psychiatry. 143 (4): 332–7. doi:10.1192/bjp.143.4.332. PMID 6626852.
  44. Helgason AR, Adolfsson J, Dickman P, Arver S, Fredrikson M, Göthberg M, Steineck G (1996). "Sexual desire, erection, orgasm and ejaculatory functions and their importance to elderly Swedish men: a population-based study". Age Ageing. 25 (4): 285–291. doi:10.1093/ageing/25.4.285. PMID 8831873.
  45. Emma Hitt (May 29, 2009). "Gene Therapy May Offer Long-Term Impotence Remedy". Reuters Health.
  46. "Erectile Dysfunction :: Gene therapy for erectile dysfunction shows promise in clinical trial". SpiritIndia. December 1, 2006.
  47. George J. Christ; Karl-Erik Andersson; Koudy Williams; Weixin Zhao; Ralph D'Agostino Jr.; Jay Kaplan; Tamer Aboushwareb; James Yoo; Giulia Calenda; Kelvin P. Davies; Rani S. Sellers; Arnold Melman (December 2009). "Smooth-Muscle–Specific Gene Transfer with the Human Maxi-K Channel Improves Erectile Function and Enhances Sexual Behavior in Atherosclerotic Cynomolgus Monkeys". European Urology. 56 (6): 891–1104. doi:10.1016/j.eururo.2008.12.016.
  48. Hernandez, Vladimir (4 May 2007). "Spider venom could boost sex life". BBC News.
  49. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol).
  50. There is evidence from several studies that supplementation with French maritime pine bark extract improves inflammatory symptoms in vivo. Evidence that pine bark extract exerts effects by inhibition of eicosanoid generating enzymes which is consistent with reported clinical anti-inflammatory and platelet inhibitory effects in vivo. Biomed Pharmacother. 2005.
  51. Cormio, L., De Siati, M., Lorusso, F., Selvaggio, O., Mirabella, L., Sanguedolce, F., & Carrieri, G. (2011, January). Oral l-citrulline supplementation improves erection hardness in men with mild erectile dysfunction [Abstract]. Urology, 77(1), 119-122. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21195829
  52. Engelhardt, P. F., Daha, L. K., Zils, T., Simak, R., Konig, K., & Pfluger, H. (2003, October). Acupuncture in the treatment of psychogenic erectile dysfunction: First results of a prospective randomized placebo-controlled study [Abstract]. International Journal of Impotence Research, 15(5), 343-346. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14562135
  53. Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994, January). Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study [Abstract]. The Journal of Urology, 151(1), 54-61. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8254833
  54. Jang, D. J., Myeong, S. L., Byung-Cheul, S., Young-Cheoul, L., & Ernst, E. (2008, October). Red ginseng for treating erectile dysfunction: A systematic review. British Journal of Clinical Pharmacology, 66(4), 444–450. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561113/
  55. Moinard, C., Nicolis, I., Neveux, N., Darguy, S., Benazeth, S., & Cynober, L. (2008, April). Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: The citrudose pharmacokinetic study [Abstract]. British Journal of Nutrition, 99(4), 855-862. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17953788
  56. Reiter, W. J., Pycha, A., Schatzl, G., ... Marberger, M. (1999). Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study. Urology, 53(3), 590-595. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10096389
  57. Ayta IA1, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int. 1999 Jul;84(1):50-6. Results: It is estimated that in 1995 there were over 152 million men worldwide who experienced ED; the projections for 2025 show a prevalence of approximately 322 million with ED, an increase of nearly 170 million men. The largest projected increases were in the developing world, i.e. Africa, Asia and South America. http://www.ncbi.nlm.nih.gov/pubmed/10444124

Note: For additional references, refer to the Clinical Studies web page.

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