Root Causes of Type 2 Diabetes

Author Sidebar: When I was diabetic and researching in the medical libraries and on the Internet, I ran into a lot of conflicting and confusing information about how to treat Type 2 diabetes.

I received a lot of suggestions from good-intended people about what I should do about my diabetes. To complicate matters, I discovered that it was actually pretty easy to lower my blood sugar by fasting or eating a low-carb-high fat or low-carb-high protein diet. But, these diets didn't address the actual root causes of Type 2 diabetes! So, at the end of the day, you may lower your blood sugar (temepaorrotily), but, you're still diabetic!

During my research, I couldn't find any diabetes book or program that clearly identified the root causes of Type 2 diabetes and how the disease develops. And, if none of these books or programs could identify the root causes, then, how can they provide a solution that would actually work? [This is how engineers think :-)]

As a result, I decided to go back and take a look at Type 2 diabetes at the cellular level (e.g. cell biology, pathology, pathogenesis) to better understand how the disease develops and what actually causes the disease. Then, I applied various engineering tools, concepts and methodologies (e.g. ishikawa diagrams, RCA, FMEA), etc.); and, "reverse-engineered" the diabetes cellular development process!

That enabled me to design a diabetes program that would actually work, because I was able to identify the real root causes of Type 2 diabetes -- not just the symptoms. By identifying the root causes and fixing the disease, your body can actually fight back because it can now repair the cell damage caused by the diabetes!

Then, and only then, can you actually have the potential opportunity to better manage and controlyour diabetes because your body (specifically, your immune system) is able to go into "cell-repair mode" and fix the damage done to your cells and tissues!

Since there are a lot of diets and methods that can lower your blood sugar, this can be very misleading because you believe that lowering your blood sugar is fixing the problem. But, it's not -- it only addresses the symptoms of being diabetic.

And, despite what the experts say, there is no one single root cause for Type 2 diabetes. If there were, there would be a much easier solution to managing and defeating this disease.

This is why I believe that an engineer is the right person to come up with a viable solution -- a multi-faceted and customizable solution, based on medical science(i.e. disease pathology, cell biology) and consistent blood glucose testing and data analysis ...

Author Sidebar: By using various sciences such as pathophysiology, epidemiology,  etiology, cell biology and biochemistry, I performed many biological and medical analyses and developed several biological/cellular models to help me identify the 5 major root causes of Type 2 diabetes:

  1. Insulin Resistance
  2. Chronic Cellular Inflammation
  3. Oxidative Stress
  4. Protein Glycation
  5. Cellular Toxicity

However, after I expanded my research and analyses, including the research from thousands of clinical studies and references, I identified several additional major root causes and associated co-factors for Type 2 diabetes.

So, my new list of major root causes of Type 2 diabetes and their associated co-factors include the following:

  • Biochemical/Hormonal Imbalances
  • Chronic Inflammation
  • Hyperglycemia/Hyperinsulinemia
  • Insulin Resistance/Fat Storage 
  • Nutrient Deficiencies (Cell Starvation/Dehydration)
  • Oxidative Stress
  • Protein Glycation
  • Toxicity (Excess Cellular Toxic Load)
  • Immune System Impairment/Dysfunction
  • Healing & Cell Repair Dysfunction

Key Point #1: The Death to Diabetes book and program address the actual root causes of diabetes. They go beyond just addressing the high blood glucose, which is a symptom, not a root cause of being diabetic.

There are a lot of diabetes books and programs that will help to lower your blood glucose, but, you want to do more than just address the symptoms to lower your blood glucose -- you want to address the root causes in order to get rid of the diabetes! You also want to repair the damage caused by the diabetes.

FYI: Those root causes include biological processes such as chronic inflammation, oxidation, glycation, and toxicity.

The Death to Diabetes book and program provide the foundation of knowledge that you need to successfully control, manage and control your diabetes; and, prevent the complications of blindness, amputation, kidney dialysis, and heart attack.

Key Point #2: It is very important to understand that these harmful biological processes prevent you from being able to controlyour diabetes even if you lower your blood sugar! This is why some diabetes programs and diabetes diets appear to work in the short term. But, in the long term, they fail as your blood sugar and hemoglobin A1C start to go back up and don't return to their normal ranges. 

Consequently, you need a comprehensive diabetes program with multiple therapies (see below) that addresses all of these harmful biological processes!

Key Point #3: Although weight gain and obesity are co-factors for Type 2 diabetes, you do not have to be overweight to become a Type 2 diabetic. In fact about 5% to 10% of Type 2 diabetics are not overweight. This further reinforces that there is more to Type 2 diabetes than assuming that it's strictly associated with overweight and obese people.

Root Causes Diagram

There are other biological processes and root causes that fuel Type 2 diabetes, and, do not require that you be overweight or obese to become diabetic, e.g. cell inflammation, oxidative stress, excess toxicity, hormonal imbalance, biochemical imbalance, nutrient deficiency, protein glycation, genetics, immune system dysfunction. 

Root Causes of Type 2 Diabetes

So, how does Type 2 diabetes develop and how do these multiple root causes fuel the development, or pathogenesis, of Type 2 diabetes?

It usually starts with high blood glucose levels (hyperglycemia) persisting over a period of years. And, this leads to damaging biological processes including insulin resistanceprotein glycation and chronic oxidation.

And, these biological processes cause an increase in cell and tissue damage from inflammation,free radicals and glycated red blood cells.

The immune system responds to try to repair the damaged cells and tissues by triggering the inflammation process, which is the first stage in the healing process (where the body tries to repair the damaged cells and tissues).

Unfortunately, because the hyperglycemia continues and leads to more insulin resistance and fat storage, the oxidation (and the damage it causes) increases; and the inflammation continues and also increases.

As inflammation increases, it progresses towards long-term chronic inflammation, causing more damage to cells and tissues; And, this may eventually lead to immune system dysfunction and possibly an autoimmune disease (depending on other risk factors).

Inflammation also increases oxidation, which causes additional free radicals to wreak more damage to more cells and tissues, especially in the cells' mitochondria, which can affect DNA.

As you can see, these harmful biological processes feed on each other, causing more cell and tissue damage.

Inflammation also increases oxidation, which causes free radicals to wreak damage to more cells and tissues, especially in the cells' mitochondria, which can affect DNA.

Hyperglycemia feeds into hyperinsulinemia and insulin resistance, which, over time, can lead to increased fat storage and pancreatic beta cell dysfunction. These processes also feed into increasing chronic inflammation and oxidative stress.

Biochemical/hormonal imbalances are associated with insulin, cortisol, glucagon, leptin, and adrenaline, which can lead to adrenal fatigue.

As previously mentioned, ongoing hyperglycemia (along with insulin resistance) creates additional protein glycation of the red blood cells, and these damaged or glycated red blood cells cause damage to the arteries and other blood vessels as they circulate throughout the body.

Then, the body, specifically the immune system, tries to repair the damage to the artery walls. The immune cells trigger the liver to create more cholesterol (as a repair agent), which is used to patch up the damage to the artery walls.

But, during this process, the cholesterol is oxidized, creating even more damage and the formation of fatty streaks and plaque inside the artery walls. This, over time, may lead to atherosclerosis and heart disease; and, an increased risk for a heart attack or stroke.

Because of the damage done to the cells, many of them are unable to expel their waste products and toxins, which accumulate in the cells, causing an increase in free radicals as well as bacteria, viruses and other pathogens (such as candida). These pathogens excrete their own mycotoxins, which poison our cells and tissues while weakening our immune system.

And, a weakened immune system makes us more susceptible to other diseases, including autoimmune diseases. The body is also more susceptible to more frequent infections and bruises/sores that don't heal because the immune system (e.g. macrophages, white blood cells) is unable to help the body repair and heal itself.

With ongoing hyperglycemia, the kidneys try to get rid of excess blood sugar via forced urination. And, by way of the urine, the body becomes depleted of vitamins and minerals such as Vitamin B-Complex, Vitamin C, Vitamin E, magnesium, chromium and potassium. 

This leads to nutrient deficiencies, cell starvation and cell dehydration, making it even more difficult for the body to fight this disease.

Some of the more common nutrient deficiencies seen in diabetics include Vitamin C, Vitamin D, Vitamin E, CoQ10 and magnesium.

As depicted in the following flow diagram, the damage caused by these biological processes and diabetes affects many types of cells: red blood, white blood, fat, liver, kidney, skin, epithelial, nerve, brain (neuron), etc.


All of the processes associated with these root causes and co-factors feed upon each other and cause damage to multiple organs and tissues over a period of many years.

Organs Damaged from Diabetes

And, that damage eventually leads to a multitude of diseases and health problems, including: retinopathy, neuropathy, nephropathy, high blood pressure, high cholesterol, and heart disease. blindness, kidney failure, amputation, heart disease, high blood pressure, high cholesterol, chronic fatigue, obesity, heart attack and stroke.

And, these diseases and health problems can lead to major health complications such as blindness, kidney failure, amputation, heart attack and stroke.

And, yet many diabetics don't believe that this is going to happen to them! Or, they believe there's nothing that they can do to stop it -- that it's going to happen no matter what. Ironically, this denial and disbelief only guarantee the obvious outcome ... 

But, if you're reading this, then, you have a chance to do something before it's too late ...

Author Sidebar (Car Analogy): Many experts and authors refer to Type 2 diabetes as a "blood sugar" disease. That's like saying a car with engine overheating problems causing the oil light to turn on has an "oil light" problem.

High blood sugar is an indicator or a symptom of the disease -- it's not the cause of the disease.

The oil light turning on while your car is overheating is an indicator or a symptom of a car problem -- it's not the cause of your car overheating.

This is very important to understand, because if you strictly focus on the fixing the symptom (lowering your blood sugar), but, you don't address what's actually causing the disease (e.g. inflammation, oxidation, glycation), then, you can't get rid of the disease.

And, although you may have your diabetes partially under control, it will continue to progress towards diabetic complications such as blindness, kidney dialysis and amputation.

Remember the car overheating example: If you cut the wire to the oil light, the car will still continue to overheat. High blood sugar represents the oil light. So, if you lower your blood sugar (with meds), the diabetes will continue to progress and cause damage throughout your body.

As depicted in the following diagrams, you can see that there are multiple factors and processes fueling the pathogenesis and the ongoing progression of this disease.

This diagram shows how Type 2 diabetes is impacted by poor diet and other risk factors. And, as it progresses, it weakens the immune system and causes damage to blood vessels (linings).

And, the damage to the blood vessels leads to diabetic complications such as blindness, kidney failure and amputation.

Type 2 Diabetes Root Causes: Inflammation, Insulin Resistance & Glycation

This diagram shows that, due to inflammation and insulin resistance, the cell is unable to absorb glucose from the bloodstream.

And, because of this, the cell is unable to produce glucose, burn fat or remove its own toxins.

In addition, as previously mentioned, insulin resistance fuels other biological processes, including oxidation, inflammation, and glycation.

Inflammation, which is characterized by simultaneous destruction and healing of the tissue from the inflammatory process, is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. In other words, inflammation is the body’s attempt to heal itself.

Inflammation is a protective immune response that involves macrophages, white blood cells and other immune cells. These cells work together to eliminate the initial cause of cell damage/injury, clear out necrotic cells and tissues damaged from the original injury, and to initiate cell/tissue repair. (Refer to our Cell Repair web page for more details).

The classical signs of acute inflammation are pain, heat, redness, swelling, and loss of function until the cells/tissues are repaired.

Inflammation is tightly regulated by the body. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism.

In contrast, chronic inflammation may lead to a host of diseases, such as atherosclerosis, rheumatoid arthritis, periodontitis, and even cancer.

Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues.

A series of biochemical events occur, involving the local vascular system, the immune system, and various cells within the injured tissue.

Type 2 Diabetes Root Causes: Chronic Cellular Inflammation

As depicted in the diagram above, prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.

Chronic inflammation is also fueled by excess oxidation (free radical damage), which, in turn, fuels more inflammation as well as cell/DNA and mitochondria dysfunction and damage.

And, over a long period of time, this type of prolonged inflammation can lead to organ/tissue damage and increased fat storage that can lead to health problems and diseases such as heart disease, cancer, Type 2 diabetic complications, Parkinson's, Alzheimer's disease, autoimmune diseases, mitochondrial-related disorders, thyroid dysfunction, accelerated aging, ulcers, slow-healing bruises, frequent infections, etc.

Other inflammation-related health problems and diseases include asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, sinusitis, obesity, and tuberculosis.

And, to further complicate matters, most of these health problems and diseases cause more inflammation, creating a vicious cycle that leads to more tissue damage and additional health problems. 

Refer to the Anti-inflammation Foods web page for natural treatment strategies for chronic inflammation and oxidative stress.

When free radicals increase significantly, this causes an increase in oxidation, or oxidative stress.

Oxidative stress (chronic oxidation) is an imbalance between oxidants and antioxidants in favor of the oxidants, potentially leading to cell/tissue damage.

Oxidative stress occurs when our body’s production of free radicals exceeds our body’s ability to counteract or detoxify their harmful effects.

As shown in the diagram below, when oxidation gets out of control (oxidative stress), it is involved in accelerated biological aging as well as in the pathogenesis of several diseases, including atherosclerosis, cancer, Type 2 diabetes, Alzheimer's, and heart disease.

Type 2 Diabetes Root Causes: Oxidation

Glycation is a process where glucose molecules attach themselves to red blood cells, forming a crystalline (coarse) crust and creating advanced glycation end products (AGEs). See diagram below of a glycated red blood cell.

When there is an excess amount of glucose molecules in the bloodstream (i.e. hyperglycemia), this increases the amount of glycation, that is the number of glucose molecules that are attached to the red blood cells. 

These coarse glycated red blood cells cause damage to the linings of blood vessels and capillaries, which can lead to various diabetic complications, including atherosclerosis, retinopathy, neuropathy and nephropathy.

Type 2 Diabetes Root Causes: Protein Glycation

In addition, the formation of advanced glycation end products (AGEs) is accelerated in diabetics because of the increased availability of glucose.

As a result, an increase in glycated red blood cells and AGEs can be found in vascular tissues, retinal vessels, nerve cells (myelin sheath damage) and glomeruli membranes of diabetic patients, which can lead to further cell damage and various diabetic complications, including atherosclerosis, retinopathy, neuropathy and nephropathy.

We expose our bodies to toxins every day via food, water, air and the environment. Pesticides and chemical solvents are obvious toxins that most of us are aware of; but, there are thousands of other toxins that we may overlook.

For example, toxins from food (artificial sweeteners, food dye, trans fats, MSG) and water (fluoride, chlorine, arsenic) can cause serious damage to our cells and tissues, especially if we don't eat the right foods to help our organs remove these toxins from our bodies.

This constant exposure to these toxins every day puts a tremendous load on our liver, kidneys, colon and lungs to remove these toxins.

These toxins cause oxidative stress and inflammation, which cause cell and tissue damage. In addition, these toxins weaken the immune system and make it difficult for cells to produce energy and do their jobs effectively.

And, over a period of years, a toxic overload can lead to diseases such as cancer, diabetes, obesity, thyroid disease, autoimmune disease, and Alzheimer's.

Refer to the Cleanse-Detox web page for more information about these toxins and how to get rid of them.


Type 2 Diabetes Root Causes: Biochemical & Biological Cycles

This diagram shows the various metabolic, biochemical, hormonal and biological cycles and processes that fuel Type 2 diabetes. 

And, if these biological cycles and  processes are not interrupted, then, the disease will continue to progress, leading to long-term diabetic complications such as atherosclerosis, blindness, kidney failure, amputation, heart attack and stroke.

Note: For more details about these root causes and harmfulbiological processes, refer to the following web pages:

It is imperative that any diabetes program that claims that it can controlthe disease, must demonstrate that it utilizes specific multiple therapies (modalities) that address all of the multiple root causes and its co-factors. Make sense, right?

Why is this so important? Because most diabetes programs focus strictly on lowering your blood sugar, but, they do not address inflammation, oxidation, toxicity and other possible root causes and co-factors.

As a result, these programs may appear to work initially by lowering your blood sugar, but, eventually, you may hit "a wall" and not be able to lower your blood sugar further.

Another scenario: you may struggle with blood sugar stability or some infrequent high blood sugar spikes; or, you may find that if you alter your meals slightly, your blood sugar may spike or stay high too long.

FYI: Here is a diagram that depicts the multiple therapies of the Death to Diabetes Program.

Multiple Therapies of the Death to Diabetes Program to Reverse Type 2 Diabetes

If you're ready to manage and control your diabetes, then, we recommend that you start with the Death to Diabetes book.

If you want to accelerate your body's cell repair and healing, then, get the author's Power of Raw Juicing book and/or Raw Food Diet book.

If you've been diabetic for years and have been taking a lot of meds and eating poorly, then, in addition, to the above books, you may want to get the Cleanse-Detox book

If you are taking insulin or other diabetic medications that you want to wean off safely, then, get the author's How to Wean Off Drugs ebook. It provides a very structured process and flow chart to help you safely wean off the insulin and/or other drugs.

Depending on your specific health needs, here is a list of the key diabetes books and ebooks that support the multiple therapies in the diagram (above) and will help you to get beyond Stage 4 of the Death to Diabetes Program:

Where to start? If you're not sure where to get started, then, the author recommends (to first-time clients) that you start with his Death to Diabetes book and maybe the Raw Juicing book -- as long as you have a juicer or blender. 

Understanding Root Causes Saved the Author!

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 Disclaimer: This site does not provide medical advice, diagnosis or treatment.

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